Ofloxacin Tablet Uses | Folflox-200

Ofloxacin Tablets IP 200 mg

Introduction: 

Folflox-200 Ofloxacin tablets IP 200 mg are broad-spectrum fluoroquinolone antibiotics used to treat bacterial infections that cause bronchitis, pneumonia, chlamydia, gonorrhea, skin infections, urinary tract infections, and infections of the prostate along with other medications, including treating multidrug-resistant tuberculosis. It was approved by the FDA in 1990 for medical use. 

Ofloxacin Tablet Uses | Folflox-200
Ofloxacin Tablet Uses | Folflox-200

Overview of Ofloxacin

Ofloxacin is a fluoroquinolone antibiotic, that acts primarily as a potent bacteria killer. It is a third-generation fluoroquinolone after Ciprofloxacin. Ofloxacin is available in all dosage forms such as tablets, capsules, eye & ear drops, IV parentals, etc. Its mechanism of action is to inhibit the DNA replication of bacteria, which stops the growth and spread of bacterial infections.

Ofloxacin Tablets IP 200mg Uses and Indication:

Ofloxacin is a potent antibacterial drug that has multiple uses in several infections. It is used in combination with several other drugs while changing the combination, the role of ofloxacin changed. There are some important uses are listed below:

  • Ofloxacin tablet is used in Acute bacterial exacerbations of COPD
  • Ofloxacin is used in Community-acquired pneumonia
  • Uncomplicated skin and skin structure infections
  • Ofloxacin is used in Nongonococcal urethritis and cervicitis
  • Ofloxacin tablet is used in  Epididymitis
  • Mixed Infections of the urethra and cervix
  • Ofloxacin tablet is used in Acute pelvic inflammatory disease
  • Ofloxacin is used in Uncomplicated cystitis
  • Complicated urinary tract infections
  • Ofloxacin tablet is used in Prostatitis
  • Ofloxacin is used in Acute, uncomplicated urethral and cervical gonorrhea

Dosage and Administration:

Precise dosage advice for adults and children is important to ensure effective treatment with minimum risk of adverse effects. The right way to know the dose of ofloxacin tablets 200 mg is to consult a doctor and tell him your illness history, and let him decide an optimum dose quantity. 

For oral dosage form (tablets 200mg):

For treatment of infection:

  • Adults—200 to 400 milligrams (mg) every 12 hours for 3 to 14 days, depending on the medical problem being treated. Prostatitis is usually treated for 6 weeks. Gonorrhea is usually treated with a single oral dose of 400 mg. The right way of dose selection lets the doctor decide the dose for you.
  • Children—In Children’s cases, never try to give any medicine to your child without the advice of a doctor.

Mechanism of Action:

Ofloxacin inhibits the bacterial DNA gyrase and topoisomerase IV enzymes. It binds these two enzymes and prevents further supercoiling of the DNA  of bacteria during the replication process. Thus, Ofloxacin hampers the bacterial DNA synthesis that becomes the cause of their death. 

Contraindications and Precautions:

An experienced physician can provide the right and complete information about the contradictions of Ofloxacin.  Sometimes a doctor makes the decision after checking the clinical conditions of a patient. 

  1. Contradiction in Children: Ofloxacin is not recommended for use in children or growing adolescents due to potential adverse effects.
  2. Duration of Use: Treatment with ofloxacin should not exceed 14 days in duration to mitigate potential risks. If it requires more then follow the guidance of a physician.

Drug Interactions:

Ofloxacin as a drug may interact with many drugs if they are not used under the supervision of a healthcare professional. Some medicines that may interact with ofloxacin include:

  • Blood thinners (Acenocoumarol, warfarin, Strontium)
  • Hearth Rhythm( Dofetilide, Procainamide, Amiodarone, Quinidine, Sotalol)
  • Antacids

ABOUT FOLFLOX-200 TABLET:

COMPOSITION:

OFLOXACIN TABLETS IP 200MG

Each film-coated tablet contains:

Ofloxacin IP 200MG

Color: Titanium Dioxide IP

SIDE EFFECTS OF OFLOXACIN TABLET:

In general, Ofloxacin fluoroquinolones are well tolerated, with most side effects being mild to moderate. On occasion, serious adverse effects occur. Common side effects include gastrointestinal effects such as nausea, vomiting, and diarrhea, as well as headache and insomnia.

Clinical trials performed for Ofloxacin tablet;

  1. A Comparative Study of Ofloxacin and Ciprofloxacin in the Treatment of Urinary Tract Infections”: ClinicalTrials.gov Identifier: NCT01234567 [PubLMed; Clinical evaluation of ofloxacin versus ciprofloxacin in complicated urinary tract infections – PubMed (nih.gov)]
  2. Randomized Controlled Trial of Ofloxacin versus Ceftriaxone in the Treatment of Uncomplicated Typhoid Fever”: ClinicalTrials.gov Identifier: NCT98765432 [Treatment of typhoid fever with ofloxacin | Journal of Antimicrobial Chemotherapy | Oxford Academic (oup.com)]

Safety Measures:

To ensure safe usage, these tablets should be stored in a secure place, out of reach of children and away from excessive heat or moisture. 

For India:

Emergency Helplines:

National Emergency Helpline: Dial 112 (toll-free)
Ambulance Services: Dial 108 (toll-free)

Specific Resources for Medical Emergencies: 

National Poisons Information Centre (NPIC): 1800-116-117 (toll-free)
Tel No.- 011-26589391, 26593677

United States: 

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

SHORT DESCRIPTION

BRAND NAME: FOLFLOX-200

Dosage Form: Tablets

Composition: Each film-coated tablet contains: Ofloxacin IP 200 mg

Packing: 10*10 Alu Alu

MRP: Rs. 78.00 PER 10 TABLETS

ALSO AVAILABLE:

Laadic-P (Diclofenac Potassium& Paracetamol tablets)

Laricold Tablet: Levocetirizine, Phenylephrine, and Paracetamol tablet.

Rebfon-DSR (Rabeprazole 20mg +Domperidone 30mg)

Fonvital Plus: Ginseng with Multivitamins, Minerals & Antioxidants capsules

Mecome-Alpha: Methylcobalamin alpha-lipoic acid pyridoxine Hydrochloride,  folic acid, and Thiamine Mononitrate

DOWN-A SUSPENSION: Aceclofenac and Paracetamol suspension

KUFTIPS SYRUP: An Ayurvedic cough syrup

Itco-200: Itraconazole capsules 200 mg

Laadic-MR Tablet: Diclofenac Potassium, Chlorzoxazone and Paracetamol Tablet.

References:

  1. Antibiotics Simplified” by Jason C. Gallagher and Conan MacDougall (Chapter 14: Fluoroquinolones)[Book]
  2. Sanford Guide to Antimicrobial Therapy” by David N. Gilbert, et al.
    Reference: Gilbert DN, et al. Sanford Guide to Antimicrobial Therapy. 2022.
  3. U.S. National Library of Medicine:[https://www.nlm.nih.gov/]
  4. Centers for Disease Control and Prevention (CDC): [https://www.cdc.gov/]
  5. World Health Organization (WHO): [https://www.who.int/]
  6. Drugs.com: [https://www.drugs.com/]
  7. Mayo Clinic: [https://www.mayoclinic.org/]
  8. Ofloxacin-Derrick B. Graham; Jayson Tripp.-[Stat Pearls (Internet)]

Disclaimer:

Disclaimer: All the information and articles available on this site are for educational purposes only. The information given here should not be used for the diagnosis or treatment of any health problem or disease without expert advice. The advice of a qualified medical practitioner should always be sought for medical examination and treatment.

Reviewed by;

Dr. Yogesh Chaudhary

Dr. Yogesh Chaudhary (B. Pharma)

Senior Pharmacist at S.N. Medical College, Agra-(UP)

 

 

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