Lace-P Tablet | Aceclofenac and Paracetamol Tablets

Lace-P tablet i.e. Aceclofenac and Paracetamol tablets are a fixed-dose combination of two medications that are used to relieve pain and fever. In this combination, Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID) whereas Paracetamol is an antipyretic and analgesic medicine. 

Aceclofenac and Paracetamol tablets are taken by mouth. They usually start working on pain and fever within 30 minutes. This combination has the most common side effects such as nausea, vomiting, and diarrhea. In very rare cases liver damage and kidney damage are possible.  

In combination, Aceclofenac and Paracetamol are more effective than taking them alone for the above-mentioned symptoms.

Lace-P tablet is a combination of Aceclofenac and Paracetamol (100mg: 325mg). It is used for severe and mild fever, body pain, joint pain, arthritis pain, and headache.

Pharmacological Profile of Lace-P Tablet

Aceclofenac:

Aceclofenac is a nonsteroidal anti-inflammatory drug (NSAID). It is used for pain relief and inflammation in several types of arthritis. It works by inhibiting isoforms of the COX enzyme that has a key role in the inflammatory cascade. [1]

Aceclofenac is used to relieve pain and Inflammation. It is a derivative of Diclofenac. It is widely used for osteoarthritis pain.

Aceclofenac is known for its COX-2 selectivity. It targets COX-2 enzyme a reason for inflammation. It helps in reducing side effects on the stomach compared to other NSAIDs like Diclofenac, etc.

Aceclofenac is a NSAID. It has many types of mechanisms of action in different symptoms. Primarily, it inhibits the cyclooxygenase (COX) activity that decreases the production of prostaglandins (PGE2) by inflammatory cells by inhibiting IL-Beta and tumor necrosis factors in the inflammatory cells. [2]. Second, it inhibits the production of cytokines, interleukins, and necrosis factors (TNF).  

Paracetamol

Paracetamol is also known as Acetaminophen and Para-hydroxy acetanilide. It is the top medicine used to treat fever and mild body pain. It blocks the release of a chemical that is a messenger responsible for pain and fever. It is an antipyretic and analgesic class medicine.[3] 

It may be hepatotoxic at high doses but in Lace-P tablet it is only a 325mg dose, its combination with NSAIDs (Aceclofenac) enhances therapeutic outcomes.

Paracetamol blocks the action of the cyclooxygenase (COX) enzyme which is responsible for the production of prostaglandins[4].

It is capable of activating the pathways in the human brain that are responsible for pain transmission [5] 

Lace-P Tablet’s Dosage: 

Always follow the instructions of a health professional about the dosage of Lace-P tablet (Aceclofenac 100mg+ Paracetamol 325 mg Tablet). As per CIMS, this tablet can be taken one tablet two times a day. 

Aceclofenac and Paracetamol Tablets Uses

Lace-P tablet is used for mild to high fever, body pain, arthritis pain, joint pain, toothache, headache, etc.

Synergycal action of Aceclofenac and Paracetamol Tablets

In the Lace-P tablet, two medicines are presented Aceclofenac (NSAID, painkiller) and Paracetamol (an antipyretic). The presence of two strong antiinflammatory and painkiller molecules makes it a very potent combination against many types of pain due to various reasons.

Aceclofenac and Paracetamol tablets in India

Brand Name	Company	MRP (₹)	Composition (mg)
Zerodol P	Ipca Laboratories	73	Aceclofenac 100 + Paracetamol 325
Hifenac P	Intas Pharmaceuticals	108.5	Aceclofenac 100 + Paracetamol 500
Dolokind Plus	Mankind Pharma	82.8	Aceclofenac 100 + Paracetamol 500
Movexx P	Cipla Ltd.	74.41	Aceclofenac 100 + Paracetamol 500
Aldigesic P	Alkem Pharmaceuticals	120	Aceclofenac 100 + Paracetamol 325
New Cyclopam Fast Relief	Indoco Remedies	60.4	Aceclofenac 100 + Paracetamol 500
Acemiz Plus	Lupin Ltd.	119.75	Aceclofenac 100 + Paracetamol 500

Other Pain Management Products

• Lace-SP tablet: (Aceclofenac 100mg+ Paracetamol 325 mg+ Serratiopeptidase 15 mg Tablet)
• Laadic-MR tablet: (Diclofenac Sodium 50mg+ Paracetamol 325mg + Chlorzoxazone 250mg Tablet)
• Laadic-P tablet: (Diclofenac Potassium 50mg+ Paracetamol 325mg)

Other NSAIDs annual worldwide consumption/Market

Medication	Estimated Annual Sales (Units)	Uses	Specific Role	Additional Information
Acetaminophen (Tylenol)	290 Billion doses	Fever, mild to moderate pain	Analgesic, antipyretic	Overdose can be fatal
Ibuprofen	1.43 Billions USD	Pain, fever, inflammation	Analgesic, anti-inflammatory, antipyretic	Can cause stomach upset, bleeding
Naproxen	15000 Tonnes	Pain, inflammation	Analgesic, anti-inflammatory	Longer-lasting than ibuprofen, can cause stomach upset, bleeding
Aspirin	40000 Tonnes	Pain, fever, inflammation, heart attack, stroke prevention	Analgesic, anti-inflammatory, antipyretic, antiplatelet	Can cause stomach upset, bleeding, Reye’s syndrome risk in children
Diclofenac	14 million units	Moderate to severe pain	Opioid analgesic	Potential for addiction and abuse

Side Effects of Lace-P Tablet

There are not any serious side effects of this combination discovered, usually, side effects of the Lace-P tablet are short and timely and disappear as the body adjusts to the medication. Some common side effects are:

• Diarrhea
• Heartburn
• Nausea
• Loss of appetite in some cases
• Pain in stomach
• Epigastric pain

SHORT DESCRIPTION

• Brand Name: LACE-P
• Dosage Form: Tablets
• Composition: Aceclofenac 100 mg.+Paracetamol 325mg
• Packing: 10×10 Alu alu
• MRP: 60 PER 10 TABLETS

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How to use Pain Medicines safely?

According to the FDA guidelines, pain medicines should not be used for a long time without the permission or guidance of a healthcare professional. If you are taking medicines for other diseases, ask your doctor before taking any pain or analgesic medicine. Do not use category antihistamines and benzodiazepines when you are using NSAIDs or analgesic medicines. Never drink alcohol in the course of pain medicines. 

FAQ

References:

1. Aceclofenac-[Drugbank online]
2. Aceclofenac Pharmacology [MedicineIndia]
3. Paracetamol [Drugs.com]
4. Paracetamol – An old drug with new mechanisms of action [Wiley Online Library]
5. Physiology, Fetal Circulation;by-Kailey Remien; Sapan H. Majmundar.[NIH]
6. U.S. Food and Drug Department
7. CIMS magazine
8. National Library of Medicines
9. Cao Z, Han K, Lu H, Illangamudalige S, Shaheed CA, Chen L, McLachlan AJ, Patanwala AE, Maher CG, Lin CC, March L, Ferreira ML, Mathieson S. Paracetamol Combination Therapy for Back Pain and Osteoarthritis: A Systematic Review and Meta-Analyses. Drugs. 2024 Aug;84(8):953-967. doi: 10.1007/s40265-024-02065-w. Epub 2024 Jun 28. PMID: 38937394; PMCID: PMC11343817.
10. Khan, S., Andrews, K. L., & F., J. P. (2018). Cyclo-Oxygenase (COX) Inhibitors and Cardiovascular Risk: Are Non-Steroidal Anti-Inflammatory Drugs Really Anti-Inflammatory? International Journal of Molecular Sciences, 20(17), 4262. https://doi.org/10.3390/ijms20174262
11. Patel PB, Patel TK. Efficacy and safety of aceclofenac in osteoarthritis: A meta-analysis of randomized controlled trials. Eur J Rheumatol. 2017 Mar;4(1):11-18. doi: 10.5152/eurjrheum.2017.160080. Epub 2017 Mar 1. PMID: 28293447; PMCID: PMC5335881.
12. Decode the future of Paracetamol-[ChemAnalyst]

Reviewed by;

Dr. Yogesh Chaudhary (B. Pharma)

Senior Pharmacist at S.N. Medical College, Agra-(UP)

Disclaimer:

Disclaimer: All the information and articles available on this site are for educational purposes only. The information given here should not be used for the diagnosis or treatment of any health problem or disease without expert advice. The advice of a qualified medical practitioner should always be sought for medical examination and treatment.