Product monograph · updated 28 October 2026
Pantafon-DSR is Laafon Galaxy’s brand of pantoprazole and domperidone capsules: pantoprazole 40 mg in gastro-resistant (enteric-coated) form plus domperidone 30 mg, of which 10 mg is released immediately and 20 mg slowly. It is a Schedule H prescription medicine used for acid reflux (GERD) when a doctor also wants to speed up stomach emptying.
The detail most pages miss: one capsule already contains 30 mg of domperidone, the full daily ceiling the European Union set in 2014 because of heart-rhythm risk[1]. A second capsule in the same day would double it. The capsule is built for once-daily use, under a doctor’s direction.
- CompositionPantoprazole 40 mg (EC) + Domperidone 30 mg (10 IR + 20 SR)
- ClassProton pump inhibitor + peripheral D2 blocker (prokinetic)
- Legal statusSchedule H · Rx only
- Pack · MRP10 × 10 Alu-Alu · ₹110 per strip of 10
What is inside a pantoprazole gastro-resistant and domperidone prolonged-release capsule
The label name, “Pantoprazole Gastro-resistant and Domperidone Prolonged-release Capsules IP”, describes three different release systems packed into one hard gelatin capsule. Each one exists for a reason.
Schematic only, to show the order of release. It is not a measured dissolution profile.
Why pantoprazole is “gastro-resistant”
Pantoprazole is broken down by stomach acid, so it is coated to pass through the stomach intact and release in the intestine. That is why it is a delayed-release medicine and should be swallowed whole, not chewed or crushed[2]. Earlier versions of this page described it as immediate-release (IR). That was incorrect: the Pantafon-DSR carton states EC (enteric-coated).
Why domperidone is split 10 + 20 mg
The 10 mg immediate-release part acts early. The 20 mg sustained-release part keeps a lower level going for longer, so one capsule can replace three separate 10 mg tablets. The total is still 30 mg a day, which is why the daily ceiling matters.
How pantoprazole and domperidone work together
Pantoprazole: cuts acid production
A proton pump inhibitor. It reduces the amount of acid the stomach makes[2]. In the US label, 40 mg once daily for up to 8 weeks is the adult dose for healing erosive oesophagitis caused by GERD, and 40 mg twice daily is used for Zollinger-Ellison syndrome[3].
Domperidone: moves the stomach along
A dopamine blocker that acts mainly outside the brain. It raises lower oesophageal sphincter pressure and increases stomach movement, so food and acid spend less time where they cause reflux[4]. It is also an anti-sickness medicine.
What the evidence shows
A 2022 meta-analysis pooled 11 randomised trials with 841 patients comparing a PPI plus domperidone against a PPI alone in GERD. The combination gave a greater reduction in overall GERD symptoms, and side effects were similar in both groups[4].
Practice in India is less tidy. A 2025 study of 8,839 outpatient prescriptions at tertiary hospitals found domperidone + PPI combinations in 481 of them. In 55% the dose was not written at all, and only 10.81% were for nausea and vomiting, the one use the EU still allows for domperidone[5]. The authors concluded that prescribing of these combinations was often not rational.
Pantafon-DSR dose: how to take pantoprazole and domperidone SR capsules
| Point | What applies | Why |
|---|---|---|
| How many | One capsule a day, or as your doctor prescribes. Never two in one day unless a doctor has deliberately chosen that. | Each capsule is 30 mg domperidone. The EU limits adults to 10 mg up to three times a day, 30 mg in total[1]. |
| When | Before a meal, usually before breakfast. | Domperidone absorption is delayed if taken after food[6]. PPIs work best taken 30–60 minutes before a meal[5]. |
| How | Swallow whole with water. Do not chew or crush. | The enteric coat protects pantoprazole from stomach acid[2]. |
| How long | The shortest course that controls symptoms. Review with your doctor if you need it for more than a week. | The EU says domperidone should not normally be used for longer than one week[1]. Long-term PPI use carries its own risks (see side effects). |
| Missed dose | Skip it and take the next one at the usual time. Do not double up. | Domperidone label instruction[6]. |
| Children | Not an adult capsule for children. Doctors use separate, weight-based products. | Below 35 kg, domperidone is dosed at 0.25 mg per kg[1]. |
Scroll the table sideways to see all columns.
Before taking it: a 4-question safety check
Domperidone’s heart-rhythm risk is concentrated in specific groups. Answer these four questions to see whether any of the label’s red flags apply. It is a prompt for a conversation with your doctor or pharmacist, not a clearance.
1. Do you have a heart-rhythm problem, heart failure or a low potassium or magnesium level, or do you take a medicine that affects heart rhythm?
2. Are you taking itraconazole, ketoconazole or another oral azole antifungal, clarithromycin or erythromycin, or HIV protease inhibitors?
3. Do you have moderate or severe liver disease?
4. Are you over 60, or already taking another medicine that contains domperidone?
Built from the contraindications and warnings in a current UK domperidone label (revised 31 March 2026)[6] and the EU’s 2014 restrictions[1].
Side effects and warnings
Pantoprazole
Common: headache, nausea, vomiting, diarrhoea, gas, joint pain and dizziness[2].
With long or high-dose use: the US label warns of Clostridioides difficile diarrhoea, bone fractures, vitamin B12 deficiency, low magnesium, fundic gland polyps, lupus-type skin reactions and acute kidney inflammation (tubulointerstitial nephritis)[3]. Fracture and polyp risks are highest at high doses or after a year or more of use[2].
Symptom relief on a PPI does not rule out stomach cancer, so persistent symptoms need investigation[3].
Domperidone
The serious one: QT prolongation, serious ventricular arrhythmia and sudden cardiac death. The risk is higher in people over 60, at more than 30 mg a day, and with QT-prolonging drugs or CYP3A4 inhibitors[6].
It also raises prolactin, so it must not be used with a prolactin-secreting pituitary tumour[6].
The US FDA has never approved domperidone for human use. In 2004 it warned of cardiac arrhythmia, cardiac arrest and sudden death when the drug was used to increase breast-milk supply[7].
Drug interactions to check before prescribing or dispensing
Two different mechanisms are at work. Domperidone is cleared by the liver enzyme CYP3A4, so CYP3A4 blockers raise its level[6]. Pantoprazole lowers stomach acid, which changes how some drugs are absorbed[3].
| Medicine or group | Clashes with | Label position | What happens |
|---|---|---|---|
| Itraconazole, ketoconazole and other systemic azole antifungals | Domperidone (and pantoprazole for ketoconazole) | Contraindicated | Potent CYP3A4 inhibition raises domperidone levels. With ketoconazole 200 mg twice daily, QTc rose by a mean of 9.8 ms[6]. Lower acid also reduces ketoconazole absorption[3]. |
| Clarithromycin, erythromycin, telithromycin | Domperidone | Contraindicated | CYP3A4 inhibition and added QT effect[6]. |
| HIV protease inhibitors | Domperidone | Contraindicated | Potent CYP3A4 inhibitors[6]. |
| Other QT-prolonging medicines | Domperidone | Contraindicated | Additive QT prolongation. Apomorphine is the stated exception[6]. |
| Rilpivirine-containing HIV medicines | Pantoprazole | Contraindicated | Listed as a contraindication in the US pantoprazole label[3]. |
| Diltiazem, verapamil | Domperidone | Not recommended | Moderate CYP3A4 inhibitors[6]. |
| Warfarin | Pantoprazole | Monitor | INR and prothrombin time can rise. Monitor INR[3]. |
| Methotrexate (mainly high dose) | Pantoprazole | Caution | Methotrexate levels may rise and stay high for longer[3]. |
| Iron salts, erlotinib, dasatinib, nilotinib, mycophenolate mofetil | Pantoprazole | Caution | These need stomach acid to be absorbed, so absorption falls[3]. |
Scroll the table sideways to see all columns.
Who should not take pantoprazole and domperidone capsules
- Allergy to pantoprazole, any other “-prazole” PPI (substituted benzimidazoles), domperidone or any ingredient[3][6].
- Known QT prolongation, significant electrolyte disturbance, or heart disease such as congestive heart failure[6].
- Moderate or severe liver impairment[6].
- Stomach or intestinal bleeding, blockage or perforation, where speeding up the gut could cause harm[6].
- Prolactinoma (a prolactin-secreting pituitary tumour), or phaeochromocytoma[6].
- Anyone taking the contraindicated medicines in the table above.
Pregnancy and breastfeeding: tell your doctor first. Domperidone passes into breast milk in small amounts[6]. It is not a milk-supply medicine; the FDA’s warning on that use is above[7].
Regulatory status of pantoprazole + domperidone in India (as of 28 October 2026)
| Question | Position |
|---|---|
| Prescription status | Both pantoprazole and domperidone are listed in Schedule H of the Drugs Rules, 1945[8]. That makes the capsule prescription-only, with the Rx symbol on the pack. See our Schedule H drug list (526 molecules). |
| Is the FDC approved? | CDSCO approved several PPI + domperidone FDCs between 2004 and 2008. It later declined a dexlansoprazole + domperidone combination[5]. |
| Banned FDC lists | The August 2024 prohibitions included sucralfate + domperidone combinations. The two-drug pantoprazole + domperidone FDC is not on that list. See 156 banned FDCs (2024). |
| Price control (DPCO 2013) | The FDC has no ceiling price of its own. In the current NLEM-2022 ceiling list, S.O. 1575(E) of 25 March 2026, the scheduled forms are domperidone 10 mg tablet, domperidone 1 mg/mL oral liquid and pantoprazole 40 mg injection[9]. See the DPCO 2026 ceiling price list. |
| European Union | Since the 2014 Article 31 review, domperidone is only for nausea and vomiting, at 10 mg up to three times daily, normally for no more than a week. Oral products supplying 20 mg per dose were withdrawn[1]. A 30 mg sustained-release combination like this one would not fit EU rules. |
| United States | Domperidone is not a legally marketed human drug. Access has been only through FDA expanded-access INDs, and the supplier for that programme stopped distributing after September 2025[7]. |
Indian schedules, FDC notifications and price orders are amended by gazette notification. Check the current CDSCO and NPPA position before relying on this table for a licensing or pricing decision.
Pantafon-DSR: Laafon Galaxy’s pantoprazole + domperidone SR brand
| Brand | Pantafon-DSR Capsules |
|---|---|
| Generic name | Pantoprazole Gastro-resistant and Domperidone Prolonged-release Capsules IP |
| Each capsule | Pantoprazole sodium IP eq. to pantoprazole 40 mg (enteric-coated) + domperidone IP 30 mg (10 mg immediate release, 20 mg sustained release) |
| Dosage form | Hard gelatin capsule |
| Pack | 10 × 10 capsules, Alu-Alu strips |
| MRP | ₹110 per strip of 10 (₹11 per capsule) |
| Schedule | Schedule H · Rx only |
| Marketed by | Laafon Galaxy Pharmaceuticals |
| Manufactured at | A third-party WHO-GMP certified facility |
| Storage | Store in a cool, dry and dark place. Protect from light. Keep out of reach of children. |
Distributors, stockists and chemists
For Pantafon-DSR rates, availability and supply to your area, message the Laafon Galaxy team directly.
Pantafon-DSR enquiry on WhatsAppOther acid-reflux products in the Laafon range
- Pantafon-40 Tablet
Pantoprazole 40 mg alone, without domperidone - Pantafon-D Tablet
Pantoprazole + domperidone tablet - Rebfon-DSR Capsules
Rabeprazole 20 mg + domperidone SR 30 mg - Omeon-D Capsules
Omeprazole 20 mg + domperidone 10 mg - Pantafon-40 Injection
Pantoprazole 40 mg vial, hospital use
पैंटाफ़ॉन-DSR: हिंदी में संक्षेप
- क्या है: पैंटोप्राज़ोल 40 mg (गैस्ट्रो-रेज़िस्टेंट) और डोमपेरिडोन 30 mg (10 mg तुरंत, 20 mg धीरे-धीरे रिलीज़) का कैप्सूल। शेड्यूल H की दवा है, केवल डॉक्टर के पर्चे पर मिलती है।
- किसलिए: एसिडिटी और एसिड रिफ्लक्स (GERD) में, जब डॉक्टर पेट को जल्दी खाली करने वाली दवा भी देना चाहते हैं।
- कैसे लें: आम तौर पर दिन में एक कैप्सूल, नाश्ते से पहले, पूरा निगलें, चबाएँ नहीं। डॉक्टर के बताए अनुसार ही लें।
- एक दिन में दो कैप्सूल नहीं: एक कैप्सूल में ही 30 mg डोमपेरिडोन है। यूरोप में यही पूरे दिन की अधिकतम सीमा है, क्योंकि इससे ज़्यादा पर दिल की धड़कन का खतरा बढ़ता है।
- सावधानी: दिल की बीमारी, लिवर की बीमारी, 60 वर्ष से अधिक उम्र, या इट्राकोनाज़ोल, क्लैरिथ्रोमाइसिन जैसी दवाओं के साथ डॉक्टर से पूछे बिना न लें।
- कीमत: ₹110 प्रति 10 कैप्सूल की स्ट्रिप (MRP)।
Frequently asked questions
It is prescribed for acid reflux (GERD) and acid-related symptoms when a doctor also wants a prokinetic to speed stomach emptying. Pantoprazole reduces acid, and domperidone improves stomach movement and raises lower oesophageal sphincter pressure.
Not unless your doctor has specifically decided on it. Each capsule contains 30 mg of domperidone, the maximum daily dose the EU allows for adults. Two capsules would give 60 mg, and the risk of serious heart-rhythm problems is higher above 30 mg a day.
Before food, usually before breakfast. PPIs work best taken 30 to 60 minutes before a meal, and domperidone is absorbed more slowly after food. Swallow the capsule whole with water.
For the shortest time that controls symptoms. The EU advises that domperidone should not normally be used for more than a week. Using pantoprazole for a year or more is linked to fractures, low magnesium, vitamin B12 deficiency and stomach polyps. Ongoing symptoms need a doctor’s review, not repeat strips.
No. Systemic azole antifungals such as itraconazole and ketoconazole are potent CYP3A4 inhibitors and are contraindicated with domperidone, because they raise its level and the risk of QT prolongation. The same applies to clarithromycin, erythromycin and HIV protease inhibitors.
No. It is a Schedule H prescription combination. The FDC prohibitions of August 2024 covered sucralfate + domperidone combinations, not pantoprazole + domperidone. Domperidone is restricted in the EU and not approved in the US, so this combination is mainly an Indian-market product.
The MRP is ₹110 for a strip of 10 capsules, about ₹11 per capsule. It is supplied in 10 × 10 Alu-Alu packs.
Darshan Singh, M.Sc. Organic Chemistry. 23+ years in pharmaceutical QC, QA and drug regulatory affairs.
Yogesh Chaudhary, B.Pharm, registered pharmacist.
28 October 2026. Clinical labels and Indian regulatory sources checked on this date.
References
- European Medicines Agency. Domperidone-containing medicines: Article 31 referral (EMEA/H/A-31/1365). CMDh position April 2014; European Commission decision 1 September 2014. Amsterdam: EMA; 2014. Available from: https://www.ema.europa.eu/en/medicines/human/referrals/domperidone-containing-medicines. Accessed October 2026.
- MedlinePlus [Internet]. Bethesda (MD): National Library of Medicine (US). Pantoprazole. Available from: https://medlineplus.gov/druginfo/meds/a601246.html. Accessed October 2026.
- Wyeth Pharmaceuticals (Pfizer). PROTONIX (pantoprazole sodium) delayed-release tablets and oral suspension: US prescribing information. Revised June 2023. DailyMed, National Library of Medicine. Available from: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=08098cb2-c048-4640-f387-6beec4a38936. Accessed October 2026.
- Zamani NF, Sjahid AS, Tuan Kamauzaman TH, Lee YY, Islam MA. Efficacy and safety of domperidone in combination with proton pump inhibitors in gastroesophageal reflux disease: a systematic review and meta-analysis of randomised controlled trials. J Clin Med. 2022;11(18):5268. doi:10.3390/jcm11185268. Available from: https://pubmed.ncbi.nlm.nih.gov/36142915/. Accessed October 2026.
- Shukla AK, Khasbage SU, Jhaj R, Sadasivam B, Cherian JJ, Chugh PK, et al. Prescribing trends of fixed-dose combination of domperidone and proton-pump inhibitor across tertiary care centers in India, is the combination rational? Indian J Pharmacol. 2025;57(3):159-165. doi:10.4103/ijp.ijp_744_23. Available from: https://pubmed.ncbi.nlm.nih.gov/40632092/. Accessed October 2026.
- Novumgen Limited. Epzit 10 mg orodispersible tablet (domperidone): Summary of Product Characteristics, sections 4.2-4.6. Date of revision of the text 31 March 2026. electronic medicines compendium (emc). Available from: https://www.medicines.org.uk/emc/product/101741/smpc. Accessed October 2026.
- US Food and Drug Administration. How to request domperidone for expanded access use. Silver Spring (MD): FDA; content current as of 4 August 2025. Available from: https://www.fda.gov/drugs/investigational-new-drug-ind-application/how-request-domperidone-expanded-access-use. Accessed October 2026.
- Central Drugs Standard Control Organisation. The Drugs Rules, 1945: Schedule H (prescription drugs), as amended. New Delhi: Directorate General of Health Services, Ministry of Health and Family Welfare, Government of India. Available from: https://cdsco.gov.in/opencms/opencms/en/Acts-and-rules/Drugs-Rules/. Accessed October 2026.
- Ministry of Chemicals and Fertilizers, Department of Pharmaceuticals (National Pharmaceutical Pricing Authority). Notification S.O. 1575(E): revision of ceiling prices of 767 scheduled formulations under Schedule-I (NLEM 2022) of the Drugs (Prices Control) Order, 2013. Gazette of India, Extraordinary, Part II, Section 3(ii); 25 March 2026. Available from: https://nppa.gov.in/en/1575e. Accessed October 2026.