Ceffon-200 | Cefixime Tablets IP 200 mg | Effective antibiotic treatment

CEFFON-200 Cefixime tablets IP 200 mg are Antibiotics of the Cephalosporin group. They are very famous antibiotics used all over the world. This is a safe antibiotic that has very few adverse effects. To reduce the adverse effects of Cefixime Ceffon-200 Tablet contains the Lactic acid bacillus 60 million spores which ease the stomach in the long use of antibiotics.

Cefixime Tablets IP 200 mg uses:

Cefixime 200mg Tablet is an antibiotic medicine that is used to treat a number of bacterial infections. These infections are mainly otitis media, strep throat, pneumonia, urinary tract infections, gonorrhea, and Lyme disease. For gonorrhea typically only one dose is required for a full cure. Cefixime works by stopping the growth of bacteria.

It is very effective against gram-positive bacteria, However, these days Cefixime+Ofloxacin tablets are also used in such conditions.

SIDE EFFECTS:

CEFIXIME: Ceffon-200 Tablet’s Side effects of Cefixime drug reactions include diarrhea, dyspepsia, nausea, and vomiting. Hypersensitivity reactions like skin rashes, urticaria, and in some cases Stevens-Johnson syndrome have been reported.  There is no specific antidote reported for Cefixime overdosage. Gastric lavage may be performed. The dialysis process does not remove Cefixime in significant quantities.

DRUG INTERACTIONS WITH CEFFON-200 TABLET:

Alcohol – No major interaction has been observed between cefixime and alcohol, So patients can drink alcohol with a mention if he is habitual of drinking. In very rare cases cefixime may cause false-positive results with certain diabetic urine testing products

HOW CEFIXIME 200MG TABLETS WORK:

The bactericidal action of Cefixime is due to the inhibition of cell wall synthesis. It binds to one of the penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of the peptidoglycan synthesis in the bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death.

Absorption Only 40–50% is absorbed from the GI tract (oral bioavailability). Absorption may be decreased when taken with food. The average peak concentration after administration of oral suspension is approximately 25–50% greater than the peak concentration following oral tablet or capsules administration

FREQUENTLY ASKED QUESTIONS ABOUT THE CEFIXIME TABLET:

Clinical Trial Studies on Cefixime Tablets

Pharmacokinetics and Bioavailability:

• Comparative Study on Formulations of Cefixime:
  P Montay Gruel et al. (1991) compared the bioavailability of 200 mg and 400 mg cefixime tablets with aqueous solutions. In that study, he concluded that tablets exhibit equivalent bioavailability and are suitable for oral administration.
  [Source: Montay et al., Drugs, 1991. Springer]
• Clinical Pharmacokinetics:
  Ajmal et al. (2023) systematically reviewed cefixime’s pharmacokinetics in healthy and diseased states, He emphasized that optimized dosing of cefixime is effective for renal impairment.
  [Source: Ajmal et al., Xenobiotica, 2023. Taylor & Francis]

Formulations and Innovations

• Oral Disintegrating Tablets:
  Remya et al. (2010) evaluated oral disintegrating tablets (ODTs) of cefixime, focusing on patient compliance and rapid dissolution, which are advantageous for pediatric and geriatric use.
  [Source: Remya et al., Journal of Young Pharmacists, 2010. ScienceDirect]
• Impact on Gastro retentive Systems:
  Kumar and Singh (2011) developed a gastro retentive system for cefixime trihydrate to enhance drug release in the stomach for extended efficacy.
  [Source: Kumar & Singh, Int J Drug Dev Res, 2011. ResearchGate]

Analytical Methods

• Simultaneous Estimation:
  Methods like RP-HPLC and HPTLC have been validated for simultaneous estimation of cefixime with other drugs (e.g., cloxacillin). Wankhede et al. (2010) and Pawar et al. (2010) highlight cost-effective and accurate methodologies.
  [Sources: Wankhede et al., 2010. ResearchGate, -Pawar et al., Asian J Research Chem, 2010.]

Impact on Microflora

Nord et al. (1988) examined the effects of cefixime on intestinal microflora, observing a minimal disruption, which supports its safety profile.
[Source: Nord et al., Scandinavian Journal of Infectious Diseases, 1988. Taylor & Francis]

Sustained-Release Tablets

Sirisolla and Ramanamurthy (2015) designed sustained-release tablets using polymers like HPMC, achieving prolonged drug action.
[Source: Sirisolla & Ramanamurthy, Indian J Pharm Sci, 2015. NCBI]

Table: Pharmacokinetic Parameters of Cefixime

Parameter	Value (Mean)	Remarks
Absorption	~50% (oral bioavailability)	Not affected by food
Peak Plasma Time	2–6 hours	Dose-dependent
Half-life	3–4 hours	Extended in renal impairment
Protein Binding	65%	Moderate binding

SHORT DESCRIPTION

Brand Name: CEFFON-200

Dosage Form: Tablets

Composition:  Cefixime 200mg +  Lactic acid bacillus 60 million spores

Packing: 10*10 ALU ALU DRIPOFF.

MRP: Rs. 131.00 PER 10 TABLETS

Substitutes of Ceffon-200 tablets in India:

Brand Name	Company	MRP
Omnix 200 DT Tablet	Cipla Limited	109.53/ 10 tablets strip
Cefix 200 Tablet	Cipla Limited	109.53/ 10 tablets strip
Nicef 200mg Tablet DT	Intas Pharmaceuticals Ltd	83/ 10 tablets strip
Ritecef-O 200 Tablet DT	Micro Labs Ltd	109.53/ 10 tablets strip
Topcef 200 Tablet DT	Torrent Pharmaceuticals Ltd	109.49/ 10 tablets strip

ALSO AVAILABLE:

CEFFON-OX:  Cefixime and Ofloxacin Tablet

CEFFON DRY SYRUP: (Cefixime 50mg/5ml)

LAADIC-MR :Diclofenac+Paracetamol+Chlorzoxazone Tablets

DOWN-650 (Paracetamol 650mg)

FEFON-XT-SYRUP: Ferrous Ascorbate eq. to elemental Iron 30mg AND Folic Acid 550 mcg

FASTER GEL: (Linseed Oil 3%, Diclofenac Sodium 1%, Methyl Salicylate 10 % and Menthol 5% Gel.)

LOBULAR-GM: (Clobetasol Propionate 0.5%, Neomycin Sulphate 0.5 %, Miconazole Nitrate  2% Cream.

Tinto-MH Cream: (Mometasone, Tretinoin, and Hydroquinone Cream)

Buy for retail shop or distribution:

Disclaimer:

Disclaimer: All the information and articles available on this site are for educational purposes only. The information given here should not be used for the diagnosis or treatment of any health problem or disease without expert advice. The advice of a qualified medical practitioner should always be sought for medical examination and treatment. Further, the information provided is for educational purposes only and should not be a substitute for professional medical advice.

References:

1. Drug Information Handbook for Infectious Diseases” by Lexi-Comp
2. Montay, G., et al. (1991). Comparative bioavailability study of cefixime administered as tablets or aqueous solution. Drugs, Springer.
3. Remya, K.S., et al. (2010). Formulation development, evaluation, and comparative study of cefixime oral disintegrating tablets. Journal of Young Pharmacists.
4. Ajmal, M., et al. (2023). Clinical pharmacokinetics of cefixime: a systematic review. Xenobiotica, Taylor & Francis.
5. Kumar, M., & Singh, B. (2011). Gastroretentive drug delivery system of cefixime. Int J Drug Dev Res. ResearchGate
6. Antibiotics Simplified” by Jason C. Gallagher
7. Sanford Guide to Antimicrobial Therapy” by David N. Gilbert
8. Drugs@FDA: FDA-Approved Drugs [https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=206939]
9. Cefixime-Oral products [FDA(.gov)] [https://www.fda.gov/drugs/development-resources/cefixime-oral-products]
10. National Library of Medicines
11. Penicillin-binding proteins articles from across Nature Portfolio [Nature Portfolio]
12. 1mg.com

Disclaimer:

Disclaimer: All the information and articles available on this site are for educational purposes only. The information given here should not be used for the diagnosis or treatment of any health problem or disease without expert advice. The advice of a qualified medical practitioner should always be sought for medical examination and treatment.

Reviewed by:

Dr. Yogesh Chaudhary (B. Pharma)

Senior Pharmacist at S.N. Medical College, Agra-(UP)