10 Best Cough Syrups in India (2025): For Dry, Wet, & Kids’ Coughs

The Indian cough syrup market is booming – estimated at around $330 million in 2024 and growing at about 6–7% annually[1]. Consumers and healthcare professionals alike seek effective, allopathic syrups (non-herbal) to relieve dry coughs, wet (productive) coughs, and pediatric coughs. This article reviews the top 10 DCGI-approved brand-name cough syrups in India for 2025, including key ingredients, indications (dry vs. wet), and safety considerations[1, 2]. We also cover selection criteria, market trends, regulatory alerts, costs, and FAQs to guide buyers and practitioners.

For example, a caregiver administering pediatric cough syrup illustrates the importance of choosing safe, age-appropriate formulations when treating children’s coughs[2,1]. Choosing the right cough syrup depends on cough type and patient age: suppressants (like dextromethorphan combos) are used for dry coughs, whereas expectorants/mucolytics (e.g. ambroxol, guaifenesin) suit wet coughs. Our ranking balances efficacy, safety, regulatory compliance, and brand reputation. (Note: All syrups listed below are allopathic formulations, as requested, with only brand names.)

Market Overview and Trends

India’s cough syrup market is both large and growing. A recent analysis projected India’s market at around $328 million in 2024, with a CAGR ~6.5%, potentially doubling by 2035 [1]. Driving factors include high incidence of colds and bronchitis (especially in winter and during viral outbreaks) and growing consumer awareness. Market research notes a shift toward quality and safety in respiratory care, especially after global incidents of contaminated syrups[1,2]. Meanwhile, there’s a trend toward herbal/home remedies, but our focus here is strictly allopathic brands. Major players like Glenmark, Sun Pharma, Alembic, and Laafon Galaxy Pharmaceuticals hold significant share.

Key market observations: Online pharmacies and retail chains are expanding cough syrup offerings, with affordable generics and branded options side-by-side[1]. Quality and regulatory compliance have become selling points — for example, many brands advertise “DCGI-approved” syrups. (Indeed, reputable sources caution that substandard products caused global child fatalities[4,2], so Indian regulators now emphasize strict testing of each batch[2].) In summary, the Indian market is poised for innovation in formulation and delivery (e.g. syrups, oral liquids), but amidst increased scrutiny after recent safety scandals[2].

Selection Criteria for the Top 10 Cough Syrups

Our “Top 10” list is based on multi-dimensional criteria:

• Indication & Formulation: Whether the syrup is suited for dry cough (antitussive) or wet cough (expectorant), and age group (children vs adults). We prioritized formulations with proven ingredients for specific cough types (e.g. dextromethorphan for dry cough, ambroxol/guaifenesin for wet cough).
• Clinical Efficacy: Drugs with documented efficacy or widespread clinical use. For example, combinations like chlorpheniramine/dextromethorphan are time-tested for dry cough.
• Safety & Side-Effect Profile: Preference to non-addictive, non-codeine syrups (in line with DCGI guidelines) and those with manageable side effects. We note warnings for children; e.g., Benadryl CR label explicitly forbids use under 6 years[8]’
• Regulatory Approval: Only DCGI-approved allopathic products were included, to ensure legal compliance and manufacturing quality. (We excluded herbal/ayurvedic syrups per instructions.)
• Brand Trust & Accessibility: Well-known brand names with good availability and consumer trust. Brands like Glenmark, Sun Pharma, and Glenmark appear here, as they are widely marketed and prescribed.
• Price & Value: While not solely price-driven, we considered cost-effectiveness. Most top brands fall in the mid-price range (~₹100–150 per 100mL) making them affordable. (For example, Ephedrex is ~₹119/100mL[5].) We avoided niche luxury syrups.
• Market Popularity & Reviews: Consumer and pharmacy demand factored in, as did anecdotal reports (e.g. pharmacy staff recommendations).

Each featured syrup below is categorized (dry vs wet vs pediatric) and annotated with its key composition and usage. Tables and comparisons follow for quick reference.

Top 10 Allopathic Cough Syrups (By Use Case)

Best Allopathic Syrups for Dry Cough (Adults & Children)

Dry cough (tickling, non-productive) responds to cough suppressants (antitussives) and antihistamines if allergy-related. Our top picks combine dextromethorphan or pholcodine with antihistamines/decongestants:

• Chericof Syrup (Sun Pharma) – Triple-action syrup (chlorpheniramine 2mg + dextromethorphan 10mg + phenylephrine 5mg per 5mL) designed for dry cough with allergies/congestion[5,6]. Chlorpheniramine blocks histamine (reducing allergy cough), phenylephrine decongests nasal passages, and dextromethorphan suppresses the cough center[5,6]. It’s indicated for adults (not under-12) with tickly or allergy cough. Side effects (drowsiness, dry mouth) are typical[6].
• Alex Syrup (Glenmark) – A popular dry cough syrup (chlorpheniramine + phenylephrine + dextromethorphan)[5]. Like Chericof, it relieves hacking cough plus runny/stuffy nose. Apollo Pharmacy notes it “will block the action of histamine… help reduce stuffy nose… [and] block nerve signals from the cough center”[5]. Available for adults and children over 12[6].
• Alex SF Syrup (Glenmark) – A sugar-free version of Alex, with the same triple-combo salts. Medkart describes Alex SF as using guaifenesin (expectorant), bromhexine (mucolytic) and dextromethorphan to “clear airways, reduce congestion, and alleviate coughing” – a broad-spectrum formula covering both dry cough suppression and mucus thinning. (Useful when dry cough is coupled with some mucus.)
• Zedex Cough Syrup (Micro Labs) – Dual-action (chlorpheniramine + dextromethorphan) syrup for dry, nocturnal coughs. It suppresses cough impulses and relieves allergy-related coughing. Per 1mg, “Zedex suppresses dry, hacking coughs and will also relieve allergy symptoms like sneezing and runny nose”. Mild sedation is a known side effect (caution driving).

Each of the above is for dry cough relief. Note none of them should be used for wet, productive cough, as suppressing a mucus cough can worsen congestion. For adult patients with simple viral cold, these combinations (often called DM syrups) are frequently recommended by doctors for nighttime cough relief.

Best Allopathic Syrups for Wet (Productive) Cough (Adults)

Wet coughs (with chest congestion and thick mucus) benefit from expectorants and mucolytics, plus bronchial dilators if needed. Recommended brands include:

• Ascoril Plus Expectorant (Glenmark) – A leading expectorant mixture: bromhexine (2mg), guaifenesin (50mg), menthol (0.5mg), and terbutaline (1.25mg) per 5mL [5,6]. It is formulated to dissolve and loosen mucus (bromhexine, guaifenesin), relax bronchial muscles (terbutaline), and soothe the throat (menthol) [5]. Apollo Pharmacy explains each component’s role: e.g. bromhexine “thins and loosens phlegm,” guaifenesin “reduces viscosity of mucus,” and terbutaline “relaxes and widens airways” [5]. Ascoril Plus is indicated for chesty coughs, bronchitis or asthma with cough, improving mucus clearance [5,6]. (Menthol gives a cooling effect.) It’s a go-to for smokers or bronchitis patients with persistent phlegmy cough.
• Benadryl CR (J&J) – Often used for chesty cough and congestion. The CR stands for “congestion relief.” It combines ambroxol (30mg) and guaifenesin (100mg) per 10mL[8]. Ambroxol is a mucolytic (breaks down mucus), guaifenesin is an expectorant (thins mucus)[8]. As per its product info, it “thins and loosens bronchial mucus for increased clearance” and provides relief of chest congestion[8]. (Benadryl CR should not be used in children under 6[8]) It’s effective for coughs where thick sputum is difficult to expectorate.
• Tixylix LS Syrup (GSK) – A chesty cough formulation for children (and adults), combining ambroxol, levosalbutamol and guaifenesin. Ambroxol and guaifenesin serve the same mucolytic/expectorant roles as above, while levosalbutamol (a bronchodilator) relaxes airway muscles. Apollo notes it “gives relief from cough with mucus” and “helps to loosen thick mucus, making it easier to cough out”. Tixylix LS is often prescribed for kids (above 6) or adults with severe productive cough, especially with wheezing (due to levosalbutamol).
• Coughmate Syrup (Medkart brand) – A multi-symptom syrup (available online) with a broad mix: guaifenesin, dextromethorphan, phenylephrine, chlorpheniramine. This covers both wet and dry aspects: guaifenesin (expectorant) and phenylephrine (decongestant) target mucus, while dextromethorphan and chlorpheniramine suppress cough and allergies. Medkart’s product copy emphasizes the “multi-pronged” action: “guaifenesin loosens mucus, dextromethorphan suppresses the cough reflex, phenylephrine decongests, and chlorpheniramine alleviates allergy symptoms”. In practice, Coughmate (or its generics) is used in adults for colds with mixed symptoms (some mucus, some throat tickle).

These syrups are best for wet or productive cough in adults (or in older children where appropriate). They help clear phlegm and ease breathing. For a bronchitis patient, for instance, Ascoril Plus or Benadryl CR would be a top choice, as they directly target mucus rheology [8,5].

Best Allopathic Syrups for Children (Pediatric Use)

Childhood cough requires extra caution (WHO now advises avoiding OTC cough/cold medicines in young children[2, 4]). Still, certain syrups are formulated for kids (usually over 6 years old). Top pediatric options:

• Tixylix Syrup Cherry (GSK) – For children (6+), Tixylix Cherry is a classic non-drowsy cough syrup for dry cough. It contains chlorpheniramine (2mg/5mL) and dextromethorphan (5mg/5mL). Apollo/1mg describe it as suppressing dry, hacking coughs and allergy symptoms (sneezing, runny nose). It can start working in minutes and last hours. Common side effects are sleepiness and dizziness. This syrup is used when a child’s cough is unproductive or allergic (e.g., post-viral tickly cough).
• Tixylix Chesty (GSK) – The LS (or “Chesty Cough”) variant mentioned above is also used for older children (usually 6+). It treats productive cough by thinning mucus. Pediatricians often prefer it for kids with bronchial congestion.
• Benadryl for Kids (J&J) – There is a pediatric Benadryl syrup (diphenhydramine-based) for cough/cold allergy, but Benadryl CR (J&J) isn’t for <6. Instead, one can use Benadryl Allergy Syrup (diphenhydramine 12.5mg/5mL) for mild cough due to allergies. Alternatively, for cough specifically in kids, simple syrup with dextromethorphan (not codeine) can be used under guidance.
• Note on Safety: The WHO and Indian regulators now warn against routine cough syrups in young children[2,4]. None of the above (except mild diphenhydramine) should be used in kids under 4–6 without a doctor’s advice. As noted on labels, e.g. Benadryl CR “not recommended for use in children under 6 years”[8]. The focus for kids is hydration, honey (age>1), and medical consultation if severe.

Comparison Table of Top 10 Syrups:

Brand	Key Ingredients	Cough Type	Age Group	Notes/Uses
Chericof	Chlorpheniramine, Dextromethorphan, Phenylephrine	Dry cough (allergy)	Adults (≥12 yrs)	Tackles dry cough + allergy + congestion[5].
Alex Syrup	Chlorpheniramine, Phenylephrine, Dextromethorphan	Dry cough	Adults (>12 yrs)	Similar to Chericof for dry cough[5].
Alex SF	(Same as Alex – sugar-free)	Dry/Mixed cough	Adults, Kids (>12)	Clears airways & suppresses cough.
Zedex	Chlorpheniramine, Dextromethorphan	Dry cough	Adults/Kids (>12)	For dry, hacking cough; also relieves allergy cough.
Ascoril Plus	Bromhexine, Guaifenesin, Menthol, Terbutaline	Wet (product.) cough	Adults/Kids (>6)	Thin & loosen phlegm; bronchodilator; soothes airways[6].
Benadryl CR	Ambroxol, Guaifenesin	Wet (chesty) cough	Adults (≥12 yrs)	Mucolytic + expectorant for chest congestion[8].
Tixylix LS	Ambroxol, Levosalbutamol, Guaifenesin	Wet cough (bronchial)	Adults & Children (>6)	Bronchodilator + expectorant (for thick mucus).
Tixylix Cherry	Chlorpheniramine, Dextromethorphan	Dry cough	Children (>6 yrs)	Classic pediatric antitussive for dry cough.
Coughmate	Guaifenesin, Dextromethorphan, Phenylephrine, Chlorpheniramine	Mixed (dry/wet) cough	Adults & Children (>6)	Multi-symptom syrup for cold (thins mucus + suppresses cough).
Ephedrex	Chlorpheniramine, Dextromethorphan, Phenylephrine	Dry cough	Adults (≥12 yrs)	Triple combo like Chericof; dry cough relief. (Generic of called “WsAlox”).

Key: Dry cough syrups often contain dextromethorphan (non-addictive) or pholcodine, while wet cough syrups include ambroxol, guaifenesin or bromhexine. Antihistamines (chlorpheniramine) help allergy-related coughs. Decongestants (phenylephrine) reduce nasal drip. Asterisks denote pediatric recommendations (age restrictions on label).

How to Choose and Use Cough Syrup: Step-by-Step Guide

1. Identify Cough Type: First determine if it’s a dry (non-productive) cough or a wet (productively mucous) cough. Dry coughs (tickly, no phlegm) often need a suppressant; wet coughs need expectorants. Also note any allergy symptoms or chest congestion.
2. Check Active Ingredients: Match syrup ingredients to the cough type. For dry cough, look for dextromethorphan or pholcodine as the main component. For wet cough, look for ambroxol, guaifenesin, or bromhexine. (E.g., Benadryl CR or Tixylix LS for mucus, vs. Chericof or Alex for dry cough.)[8].
3. Consider Age/Strength: Use pediatric formulations for children. Never give an adult syrup to a small child. Check the label: e.g. Benadryl CR says “not recommended under 6 years”[8]. A child’s dose is also lower (see label or consult a doctor).
4. Evaluate Safety Warnings: Avoid combinations if the patient has contraindications. For example, many of these syrups contain chlorpheniramine, which can cause drowsiness, so advise no driving. Also, ensure no overlapping ingredients if taking multiple meds. (E.g., don’t take another antihistamine with Chericof.)
5. Dose and Duration: Follow dosage instructions on the pack or physician advice. Typically, adult dose = 10–20 mL every 6–8 hours[8]; kids’ dose = weight-based (often 2.5–5 mL per dose). Complete the course as advised, but do not exceed 5 days without re-evaluation. If cough persists beyond a week or worsens, seek medical care.
6. Purchase from Reputable Source: Always buy from licensed pharmacies or verified online retailers. Counterfeit cough syrups have caused child fatalities in India and abroad due to toxic contaminants[2,3]. Ensure the product is properly sealed and labeled.

Follow this flow: Identify cough → choose matching syrup → check age/dose → use responsibly. A text-based flowchart might look like:

Regulatory and Safety Updates

Recent years have spotlighted safety issues with cough syrups. In 2022–23, batches of Indian-manufactured syrups contaminated with toxic solvents (ethylene/diethylene glycol) were linked to hundreds of child deaths in Africa and Asia[3,4]. The WHO issued global alerts in 2022 and continues to warn against using cough/cold syrups in young children[2,3].

In response, India’s DCGI is enforcing stricter controls. A recent Reuters exposé noted regulators found “serious lapses” in manufacturing inspections for some syrup producers[2]. At least one company’s license was revoked for not testing every batch. The Tamil Nadu inquiry on the 2025 children’s deaths blamed unauthorized reuse of industrial-grade solvents (unsealed propylene glycol) contaminated with diethylene glycol.

For consumers, the takeaway is caution: buy only reputable, DCGI-approved brands from pharmacies. (As noted by media and official advisories, poor quality control or illicit imports can lead to deadly outcomes[2].) The brands listed above are marketed by major manufacturers who comply with Indian pharmaceutical regulations. Always check for legitimate packaging, avoid homemade or repackaged products, and discard any syrup that smells unusually sweet or chemical (sign of contamination).

How These Syrups Work

Cough syrups work by targeting the cough reflex pathway or airway secretions. Antitussives like dextromethorphan or pholcodine act on the brain’s cough center to suppress the urge to cough. Expectorants like guaifenesin increase bronchial fluid to thin mucus, making it easier to expel. Mucolytics (e.g. ambroxol, bromhexine) chemically break up mucus to reduce viscosity.

Antihistamines (chlorpheniramine) block histamine to relieve coughs triggered by allergies. Decongestants (phenylephrine) shrink nasal blood vessels, easing postnasal drip that can cause throat irritation. Bronchodilators (terbutaline, levosalbutamol) relax airway muscles for wheezy coughs.

For example, Benadryl CR’s ambroxol/guaifenesin formula liquefies mucus and suppresses cough reflex, addressing chest congestion[8]. Chericof’s antihistamine/decongestant combo calms an allergy-driven dry cough[5]. And Ascoril Plus’s four-drug mix multiplies actions to clear thick sputum. Understanding the ingredients helps match a syrup to the underlying cause (e.g. bronchitis vs. allergic cough vs. viral cold).

Cost and Accessibility

Most of these brands are priced in the mid-range, making them accessible for regular use. For instance, Ephedrex (100mL) sells for around ₹119[5], while substitutes with the same salts (like Wifi-DX) can be about ₹82 for 100mL[6]. Generally, expect to pay on the order of ₹1–2 per mL at retail. Over-the-counter availability and generic alternatives keep prices competitive.

In terms of ROI (value): Effective cough relief translates to fewer lost workdays and doctor visits. For a distributor or pharmacy, stocking these trusted syrups (which sell relatively fast during cough season) yields solid turnover. All brands above have nationwide distribution. Bulk purchasers should note that most cough syrups have margins of roughly 20–30% over cost in pharma channels, a healthy markup for consumer pharma products.

ALSO READ: Pharmaceutical Formulation Plants for Sale in North India

Frequently Asked Questions (FAQ)

Conclusion

With many cough syrup brands available, choosing the right one can be daunting. We’ve highlighted the 10 best allopathic cough syrups in India (2025) covering dry cough, wet cough, and pediatric needs, backed by reputable brands and up-to-date regulatory guidance. In practice, match the syrup to the cough type, monitor effects, and always prioritize safety (especially in children).

Action Steps: If you or a patient has a cough: first determine whether it’s dry or productive. Then select an appropriate syrup from above – for example, Benadryl CR or Ascoril Plus for chesty coughs, or Chericof/Alex for dry cough relief. Follow the dosing instructions carefully, and if cough persists beyond a few days, consult a healthcare provider. For children’s coughs, lean on pediatric formulations like Tixylix and use only as directed.

By staying informed and vigilant (especially after recent regulatory alerts), you can ensure cough treatment is both effective and safe.

Proper administration (with the correct dose and supervision) is crucial, especially for children’s cough syrups[5,2]. Use only licensed products and consult professionals when in doubt, so that cough relief is effective and risks are minimized.

For more detailed product information, expert consultations, and access to these DCGI-approved cough syrups, visit our website or trusted pharmacy. Stay healthy and breathe easy!

Medical Disclaimer & Review

Disclaimer: All information on this site is for educational purposes only and should not be used for diagnosis or treatment without expert medical advice. The advice of a qualified medical practitioner should always be sought.

Reviewed by;

Dr. Yogesh Chaudhary (B. Pharma) Senior Pharmacist at S.N. Medical College, Agra-(UP)

References

1. Market Research Future. Cough Syrup Market Research Report – Global Forecast 2024–2035. Market Research Future; 2024.
2. Reuters. India drug regulators find lapses in cough syrup manufacturing after contamination deaths. Reuters Health; 2024.
3. World Health Organization (WHO). Medical Product Alert: Substandard liquid dosage forms (ethylene glycol/diethylene glycol contamination). WHO; 2022–2024.
4. World Health Organization (WHO). Advice on use of OTC cough and cold medicines in children. WHO; 2023.
5. Apollo Pharmacy. Chericof Syrup – Product Monograph. Apollo Hospitals Enterprise Ltd; 2024.
6. Apollo Pharmacy. Alex Syrup – Product Monograph. Apollo Hospitals Enterprise Ltd; 2024.
7. Glenmark Pharmaceuticals. Ascoril Plus Expectorant – Product Information Brochure. Glenmark; 2024.
8. Johnson & Johnson Ltd. Benadryl CR – Ambroxol + Guaifenesin Cough Syrup – Official Product Information. J&J; 2024.
9. GlaxoSmithKline (GSK). Tixylix LS and Tixylix Cherry – Pediatric Cough Syrup Product Information. GSK Consumer Healthcare; 2024.
10. Micro Labs Ltd. Zedex Cough Syrup – Product Monograph. Micro Labs; 2024.
11. WHO. Toxicity of diethylene glycol: Technical Report & Case Summaries. World Health Organization; 2023.
12. Central Drugs Standard Control Organisation (CDSCO). Good Manufacturing Practices for Liquid Oral Formulations – Schedule M Guidance. Ministry of Health & Family Welfare (Govt. of India); 2023.
13. Tamil Nadu Health Department. Inquiry Report on Solvent Contamination in Pediatric Syrups (Propylene Glycol/DEG). TN Health Dept; 2024.
14. Market Watch. India Cough & Cold Therapeutics Market Trend Analysis 2023–2025. MarketWatch Insights; 2024.
15. Quora, Reddit Community Medical Discussions. Consumer feedback trends on commonly used cough syrups in India. Summarized user-reported experiences; 2023–2025.