Lace-SP is a fixed-dose combination tablet containing Aceclofenac 100 mg, Paracetamol 325 mg and Serratiopeptidase 15 mg. It is used in adults for short‑term relief of pain, inflammation and swelling in conditions such as osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, musculoskeletal injuries, dental pain and post‑operative pain, strictly on a doctor’s prescription.
What Is Lace-SP Tablet?
Lace-SP is a prescription-only analgesic and anti-inflammatory tablet combining three active ingredients:
- Aceclofenac 100 mg – a non‑steroidal anti‑inflammatory drug (NSAID) that reduces pain, swelling and stiffness by inhibiting prostaglandin synthesis.
- Paracetamol 325 mg – an analgesic and antipyretic that enhances pain relief and helps control fever.
- Serratiopeptidase 15 mg – a proteolytic enzyme that helps reduce inflammation, edema and tissue swelling at the affected site.
This triple‑action formulation is widely used by orthopedicians, surgeons, dentists and general physicians for short‑term management of painful inflammatory conditions.
Composition, Pack & Specifications
Lace-SP Tablet Composition
| Parameter | Details |
|---|---|
| Brand name | Lace-SP Tablets |
| Generic name | Aceclofenac + Paracetamol + Serratiopeptidase Tablets |
| Strength | Aceclofenac 100 mg + Paracetamol 325 mg + Serratiopeptidase 15 mg |
| Dosage form | Film‑coated tablet, oral |
| Colour | Orange, film‑coated (brand‑specific) |
| Packing | 10 × 10 Alu‑Alu (100 tablets per box) |
| Storage | Store in a cool, dry and dark place below 25–30 °C, protected from moisture and light. |
| Schedule | Schedule H prescription drug (India) |
Price Information in India
| Pack | MRP (Incl. of all taxes) | PTR / PTS* (optional) |
|---|---|---|
| 10 × 10 Alu‑Alu | ₹110.00 |
How Lace-SP Works (Mechanism of Action)
The three ingredients in Lace-SP act at different points of the pain–inflammation cascade:
- Aceclofenac inhibits cyclo‑oxygenase (COX‑1 and COX‑2) enzymes, reducing synthesis of prostaglandins responsible for pain, swelling, and joint stiffness.
- Paracetamol acts mainly in the central nervous system to increase pain threshold and help reduce fever, complementing the analgesic effect of aceclofenac.
- Serratiopeptidase breaks down inflammatory proteins and fibrin at the site of injury, helping to decrease edema, improve microcirculation and promote tissue healing.
Together, the combination offers faster and more sustained relief from pain and swelling than single‑agent therapy, when used appropriately and for a short duration.
Indications & Uses of Lace-SP
Always use only on the advice of a registered medical practitioner.
Lace-SP (Aceclofenac Paracetamol Serratiopeptidase tablets) may be prescribed in adults for short‑term relief of:
- Musculoskeletal and joint disorders
- Post‑operative and post‑traumatic pain
- Other painful inflammatory conditions
- Acute dental pain (toothache)
- Muscular pain and soft‑tissue injuries
- Painful menses (dysmenorrhea), when clinically appropriate
It is not intended as a routine medicine for simple flu, common cold or mild fever unless specifically advised by a doctor.
Dosage & Administration
The exact dose, duration and frequency must be decided by the treating physician based on the patient’s condition, age, weight and co‑morbidities.
- Typical adult dose (reference only, not a prescription)
- Route of administration: Oral, swallow whole with a glass of water; do not crush or chew.
- Duration of use:
If a dose is missed, take it as soon as remembered unless it is almost time for the next dose. Do not double the dose.
Possible Side Effects of Lace-SP
Like all NSAID‑based combinations, Lace-SP may cause side effects. Many are mild and transient, but serious reactions can occur.
- Nausea, vomiting
- Stomach pain, abdominal discomfort
- Indigestion (dyspepsia), heartburn
- Diarrhea or constipation
- Loss of appetite
- Headache, dizziness, drowsiness
- Mild skin rash or itching
Serious but less common side effects
- Gastrointestinal bleeding, black or bloody stools, vomiting blood
- Severe abdominal pain or persistent heartburn
- Signs of liver injury – yellowing of eyes/skin, dark urine, severe fatigue (due mainly to paracetamol/hepatotoxicity)
- Kidney dysfunction – decreased urine output, leg swelling, breathlessness
- Severe allergic reactions – facial/lip swelling, difficulty breathing, severe skin reactions (Stevens–Johnson syndrome, toxic epidermal necrolysis, though rare)
- Worsening of asthma or bronchospasm in susceptible individuals
Seek immediate medical attention if any serious side effect or allergic reaction occurs.
Warnings, Precautions & Contraindications
Do not use Lace-SP without a doctor’s prescription. It is a Schedule H medicine.
Contraindications / When Lace-SP is usually avoided
- Known hypersensitivity to Aceclofenac, Paracetamol, Serratiopeptidase, other NSAIDs or any excipient
- Active or history of recurrent peptic ulcer or gastrointestinal bleeding
- Severe liver impairment or active liver disease
- Severe kidney impairment
- History of aspirin/NSAID‑induced asthma, angioedema or urticaria
- Severe heart failure or uncontrolled hypertension
- Known bleeding disorders or on certain anticoagulants where risk outweighs benefit
Use with caution and only under close medical supervision in:
- Elderly patients (higher risk of GI bleed, renal and CV events)
- Patients with mild-to-moderate hepatic or renal impairment
- Patients with bronchial asthma or respiratory disorders (NSAIDs may precipitate bronchospasm)
- Patients with cardiovascular risk factors (hypertension, dyslipidemia, diabetes, prior MI/stroke)
- Patients consuming alcohol regularly (increased hepatotoxicity risk with paracetamol)
- Pregnancy:
- NSAIDs like aceclofenac are generally avoided, especially in the third trimester due to risk of premature ductus arteriosus closure and labor complications. Use only if clearly needed and prescribed by a specialist.
- Breastfeeding:
- Use only if potential benefit justifies the potential risk. Discuss with the treating physician before use.
Driving & operating machines
- May cause dizziness or drowsiness in some patients. Avoid driving or operating machinery if such symptoms occur.
Alcohol
Drug Interactions
Inform the doctor about all medicines, herbal products and supplements being taken. Important potential interactions include:
- Other NSAIDs or high‑dose aspirin
- Anticoagulants (e.g., warfarin), antiplatelets
- Certain antihypertensives and diuretics (e.g., ACE inhibitors, ARBs) – possible reduced efficacy and higher renal risk
- Nephrotoxic drugs (e.g., some antibiotics)
- Other paracetamol‑containing medicines – risk of cumulative overdose
- Certain antiepileptics and rifampicin – may alter paracetamol metabolism
Overdose & Emergency Information
Because Lace-SP contains paracetamol and an NSAID, overdose can be dangerous.
- Paracetamol overdose can cause severe, sometimes irreversible liver damage.
- Aceclofenac overdose may lead to intense GI symptoms, drowsiness, dizziness, and renal complications.
If more than the prescribed dose is taken or overdose is suspected (especially in children or elderly), seek emergency medical care immediately. Do not wait for symptoms to appear.
Lace-SP for Different Audiences
For Healthcare Professionals (HCPs)
- Recommended as a short‑term FDC for acute painful inflammatory conditions where enzyme support for edema reduction is desired.
- Use with careful patient selection and risk assessment (GI, hepatic, renal, CV).
- Avoid long‑term continuous use; consider monotherapy or safer alternatives where feasible.
For Patients
- Take Lace-SP only on your doctor’s advice.
- Do not use it as a routine pain killer or for minor aches/flu.
- Do not combine with other painkillers or paracetamol products without medical advice.
- Stop the medicine and consult your doctor immediately if you notice blood in stool, severe stomach pain, yellowing of eyes/skin, breathing difficulty, or severe rash.
For Distributors & PCD/Third‑Party Clients
- Lace-SP is a high‑demand analgesic–enzyme FDC used widely in orthopedics, surgery, dental and GP practice in India.
- The 100/325/15 mg strength with Alu‑Alu packing is well‑accepted across markets.
Manufacturing & Third‑Party / PCD Opportunities
Customize this section with your actual company details.
Why Choose Laafon Galaxy for Lace-SP Manufacturing?
- WHO‑GMP / ISO‑certified facility at Karnal, Haryana
- Dedicated analgesic & anti‑inflammatory manufacturing line with validated processes
- Alu‑Alu blister packing ensuring moisture and light protection
- In‑house QC/QA with validated HPLC methods and full in‑process controls
- Batch‑to‑batch consistency, stability data and regulatory documentation support (COA, COPP where applicable)
PCD Pharma Franchise for Lace-SP
- Monopoly-based or territory‑wise PCD agreements
- Attractive margins and visual promotional inputs (MR bags, visual aids, reminder cards)
- Timely supply with robust logistics support
Third‑Party Manufacturing (Loan Licence)
- Minimum order quantity (MOQ): 500 boxes / batch
- Custom branding (own brand name/artwork) while using our approved formulation
- Regulatory dossier support as per client requirement
Similar Products in the Analgesic Range
You can internally link to related products on your site.
- Lace‑P Tablet – Aceclofenac 100 mg + Paracetamol 325 mg
- Down‑A Suspension – Aceclofenac + Paracetamol suspension
- Laadic‑SP Tablet – Diclofenac + Paracetamol + Serratiopeptidase tablet
Regulatory Note & FDC Controversy (India)
Fixed‑dose combinations (FDCs) containing NSAIDs, paracetamol and serratiopeptidase have been reviewed by Indian regulatory authorities for rationality and safety. Certain FDCs were asked to submit clinical trial data to demonstrate added benefit over simpler combinations and some irrational FDCs have been prohibited.
[YOUR COMPANY NAME] manufactures Lace‑SP strictly in line with the latest CDSCO and State FDA regulations and maintains all mandatory approvals and quality documentation. Buyers are advised to verify local regulatory status before marketing in their territory.
FAQs on Aceclofenac Paracetamol Serratiopeptidase Tablets
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Is Lace‑SP safe for long‑term daily use?
No. This combination is generally intended for short‑term use under medical supervision. Long‑term or unsupervised use increases the risk of stomach ulcers, bleeding, liver and kidney damage.
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Can Lace‑SP be taken on an empty stomach?
It is usually recommended to take Lace‑SP after food to reduce gastric irritation. Follow your doctor’s instructions.
-
Can I take another paracetamol tablet with Lace‑SP?
No, do not add extra paracetamol unless specifically advised by a doctor. Lace‑SP already contains paracetamol, and overdosing can damage the liver.
-
Is Lace‑SP safe in pregnancy or breastfeeding?
Use in pregnancy, especially during the third trimester, is generally avoided. In breastfeeding, it should only be used if clearly needed and prescribed. Always consult your gynecologist or treating physician before use.
-
Is this combination suitable for children?
Dose and suitability in children depend on age, weight and clinical condition. It should not be given to children without a pediatrician’s prescription.
References
- Aceclofenac + Paracetamol + Serratiopeptidase – uses, warnings, FAQs (1mg.com)
- Aceclofenac + Paracetamol + Serratiopeptidase – side effects & warnings (Zeelab Pharmacy)
- Sifenac‑SP (Aceclofenac 100 mg + Paracetamol 325 mg + Serratiopeptidase 10 mg) – product details (Signa)
- Bhumi Pharmaceuticals – Aceclofenac, Paracetamol & Serratiopeptidase Tablet composition & MOA
- Aceclofenac + Paracetamol SmPC / prescribing information (example SmPCs)
- CDSCO public notices on FDCs and banned combinations (India)
Reviewed by;
Dr. Yogesh Chaudhary (B. Pharma)
Senior Pharmacist at S.N. Medical College, Agra-(UP)
Disclaimer:
Disclaimer: All the information and articles available on this site are for educational purposes only. The information given here should not be used for the diagnosis or treatment of any health problem or disease without expert advice. The advice of a qualified medical practitioner should always be sought for medical examination and treatment.
