Amoxycillin and Potassium Clavulanate Tablets 625 mg i.e. Laamox-CV 625tablet, a powerful antibiotic combination, have become a cornerstone in modern medicine. This medication comprises two key components – Amoxycillin, an antibiotic that fights bacterial infections, and Potassium Clavulanate, which enhances Amoxycillin’s effectiveness by preventing bacterial resistance.
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According to a survey carried out by the National Programme on AMR Containment, “the total antibiotic consumption at the ten NAC-NET sites varied from 88.7 to 118.3 defined daily doses (DDD) per 100-bed days during the years 2017 to 2021.
Classification of antibiotics as per the WHO AWaRe classification highlights that consumption of the Watch group of antibiotics exceeded that of the Access group antibiotics in all years with proportions ranging from 52 to 73%. Tab. Amoxicillin and Clavulanic Acid 625mg (Access group), Tab. Azithromycin 500mg (Watch group), Tab. Cefixime 200mg (Watch group) and Inj. Ceftriaxone 1g (Watch group) was the most commonly used antibiotic over the years. Consumption of the Reserve group of antibiotics ranged from 1 to 5%”.
Uses and Indications:
Amoxycillin and Potassium clavulanate tablets are used to treat a spectrum of infections. Effective in respiratory tract infections to urinary tract infections.
Amoxycillin and Potassium Clavulanate Tablets 625 mg are renowned for their versatility in treating a myriad of infections. From common respiratory ailments like sinusitis and bronchitis to more complex urinary tract infections, this medication stands as a robust solution.
Some common uses of Amoxycillin and Potassium Clavulanate tablets 625mg:
- Treatment of respiratory tract infections
- Management of urinary tract infections
- Combatting sinusitis
- Effective against bronchitis
- Skin and soft tissue infections
- Treatment of ear infections
- Managing dental infections
- Combating bone infections
- Urinary tract infections in females
- Treatment of lower respiratory tract infections
- Addressing infections in the nose and throat
- Combating infections in the reproductive organs
- Management of community-acquired pneumonia
- Effective against bacterial sinusitis
- Addressing lower respiratory tract infections in children
Dosage Guidelines:
The recommended dosage of amoxicillin and clavulanate tablets 625 mg depends on the severity of the infection and the patient’s age. According to drugs.com, the general dosage is as follows:
- Oral: Adults and children over 12 years: One 375 mg tablet 3 times a day.
- In severe infection one 625 mg tablet 3 times a day or one 1 gm tablet two times a day.
- Children of 6-12 years: 2 teaspoonful Powder for Suspension (Each 5 ml contains 200:28.5mg) every 8 hours.
It is highly important to take amoxicillin and clavulanate FDCs exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Amoxicillin and clavulanate potassium may work best if you take it at the start of a meal.
Side effects of Amoxycillin/Clavulanate Tablets 625mg:
Since the Amoxycillin and Potassium Clavulanate tablets are strong antibiotics and very effective against several types of bacterial infections, therefore, it has some side effects on overuse or use without requirement. Some common side effects of these two combination medicine:
- Gastrointestinal discomfort
- Nausea
- Diarrhea
- Headache
- Dizziness
- Insomnia (rare)
- Vomiting (rare)
- Allergic reactions (severe, seek immediate medical attention)
- Skin rash
- Itching
- Swelling, especially of the face, lips, or tongue (indicative of an allergic reaction)
- Difficulty breathing (emergency situation, seek immediate medical help)
- Jaundice (yellowing of the eyes or skin)
- Dark urine
- Unusual bleeding or bruising (rare)
- Persistent sore throat or fever (indicative of secondary infection)
- Clostridium difficile-associated diarrhea (rare but serious, may occur after antibiotic use)
Mechanism of Action:
The mechanism of action of Amoxycillin and Potassium Clavulanate tablets 625 mg is illustrated below:
Inhibition of Cell Wall Synthesis: Once bound to PBPs, amoxicillin inhibits the transpeptidation reaction involved in the cross-linking of peptidoglycan chains. This disruption prevents the formation of a functional bacterial cell wall for bacteria.
Weakening and Lysis of Bacterial Cells: As a consequence of inhibited cell wall synthesis, the bacterial cell becomes structurally compromised. This weakening eventually leads to the disintegration of the bacterial cell, and it prevents its ability to maintain integrity.
Enhancement of efficiency by Clavulanate: Potassium Clavulanate, the second component in the tablet, acts as a beta-lactamase inhibitor. Beta-lactamase is an enzyme produced by some bacteria that can increase the efficiency of amoxycillin by breaking down its beta-lactam ring.
Prevention of Beta-Lactamase Action: Clavulanate binds irreversibly to beta-lactamase, which inhibits its activity. This allows amoxicillin to exert its bactericidal effects effectively, even against beta-lactamase-producing bacteria that would otherwise resist treatment.
Synergistic Bactericidal Action: The combination of amoxicillin and clavulanate in Laamox-CV 625 results in a synergistic bactericidal action. The dual mechanism of inhibiting cell wall synthesis and preventing enzymatic degradation ensures a strong response against a broad spectrum of bacteria.
Effective Against Resistant Strains: By countering beta-lactamase production, Amoxycillin and Potassium Clavulanate Tablets 625 mg (Laamox-CV 625) overcome antibiotic resistance in certain bacterial strains. This makes the medication particularly valuable in scenarios where resistance might compromise the effectiveness of other antibiotics.
Broad Spectrum of Activity: The synergistic action of amoxicillin and clavulanate extends the spectrum of activity, making these tablets effective against both Gram-positive and Gram-negative bacteria. This broad coverage enhances the versatility of the medication in treating various bacterial infections.
Absorption and Distribution:
Oral Absorption: Rapid Uptake in the Gastrointestinal Tract:
Upon oral administration, Amoxycillin and Potassium Clavulanate Tablets 625 mg undergo rapid absorption in the gastrointestinal tract. The tablets disintegrate, here it release the active ingredients into the digestive system. The permeable mucosal lining of the gastrointestinal tract allows the efficient mixing of these components into the bloodstream.
Bioavailability:
Amoxycillin and Potassium Clavulanate exhibit high bioavailability, ensuring that a significant amount of the ingested dose enters the bloodstream thus it provides a shield of protection against bacteria.
Distribution:
Once reaching the bloodstream, Amoxycillin and Potassium Clavulanate disperse widely throughout the body and address each part to eliminate the infections.
SHORT DESCRIPTION
BRAND NAME: LAAMOX-CV 625
Dosage Form: Tablets
Composition: Amoxycillin 500mg+Clavulanic acid 125mg + Lactic acid bacillus 2.5 million spores
Packing: 10*1*6 Alu alu
MRP: Rs. 158.00
Also available;
Laamox-CV: Dry syrup (Amoxycillin200mg+ Clavulanate 28.5 mg/5ml)
BELIMOX-500: Amoxycillin 500mg+Lactic Acid Bacillus 2.5 MS.
Substitutes of Laamox-CV 625 tablets in India:
| Product Name | Company | MRP (INR) |
| Amoxiclav 625 | Abbott | 204.84 |
| Clavam 625 | Alkem Laboratories Ltd. | 204.85 |
| Moxikind-CV 625 | Mankind Pharma Ltd. | 191.83 |
| Moxclav 625 | Sun Pharmaceutical Industries Ltd. | 204.84 |
| Amoxible-CL 625 | Zeelab Pharmacy Pvt Ltd. | 100 |
| Ampiclav 625 | Glenmark Pharmaceuticals Ltd. | 204.84 |
| Clavoxam 625 | Zenexa | 121 |
| Acuclav 625 | Macleods Pharmaceuticals Ltd. | 189.12 |
| Ecoclav 625 | GH Vision care | 99 |
| Augmentin 625 Duo | GlaxoSmithKline Pharmaceuticals Ltd. | 204.85 |
References:
- Surveillance of Antimicrobial Consumption under National Antimicrobial Consumption Network (NAC-NET) July 2023-[Ministry of Health and Family Welfare Government of India)]
- Amoxicillin and Clavulanic Acid-[Medline Plus(.gov)]
- Amoxycillin/Clavulanic Acid 625mg-[Medicine FAQ(.com)]
- AMOXICILLIN-CLAVULANATE POTASS Tablet – Uses, Side Effects, and More- Side Effects-[WebMD(.com)]
- Combination beta-lactamase inhibitors, carbapenems, and monobactams-[Uptodate(.com)]
Reviewed by;
Dr. Yogesh Chaudhary (B. Pharma)
Senior Pharmacist at S.N. Medical College, Agra-(UP)
Disclaimer:
Disclaimer: All the information and articles available on this site are for educational purposes only. The information given here should not be used for the diagnosis or treatment of any health problem or disease without expert advice. The advice of a qualified medical practitioner should always be sought for medical examination and treatment.
