Diclofenac Sodium Injection is a cornerstone in modern medicine for the management of acute pain and inflammation. As a potent non-steroidal anti-inflammatory drug (NSAID), its injectable form provides a rapid onset of action, making it an indispensable tool for healthcare professionals across India. This guide offers a comprehensive overview of Diclofenac Injection 75mg/ml, its clinical applications, mechanism of action, and safety profile, designed for medical practitioners and pharmaceutical distributors.
Product Fact Sheet: LAADIC Injection
| Feature | Details |
| Brand Name | LAADIC INJECTION |
| Composition | Diclofenac Sodium Injection I.P. 75 mg / 1 ml |
| Dosage Form | Injectable Solution |
| Packaging | 10×1 ml Tray Pack |
| Price | Available on request |
| Manufacturer | Laafon Galaxy Pharmaceuticals |
| Regulatory Status | Schedule H Prescription Drug |
What is Laadic Injection?
Laadic Injection is a sterile preparation of Diclofenac Sodium 75 mg in a 1 ml ampoule, manufactured by Laafon Galaxy Pharmaceuticals, a WHO-GMP certified pharmaceutical company based in Karnal, Haryana. It is formulated to meet the stringent standards of the Indian Pharmacopoeia (I.P.), ensuring quality and therapeutic efficacy for pain management.
Clinical Indications for Diclofenac Injection 75mg/ml
The intramuscular administration of Diclofenac provides rapid systemic delivery, making it highly suitable for conditions where immediate pain relief is required.
Acute and Chronic Pain Management
Diclofenac injection is highly effective for moderate to severe pain arising from various conditions, including:
- Renal colic (kidney stone pain)
- Migraine attacks
- Acute flare-ups of joint pain or gout
- Dental pain
Post-Surgical Pain and Inflammation
This NSAID injection is a vital component of postoperative pain management protocols. By inhibiting inflammation at the surgical site, it significantly reduces pain and discomfort, particularly following orthopedic, abdominal, and gynecological surgeries. Its efficacy in this area is well-documented in clinical studies.
Inflammatory Conditions
As a potent anti-inflammatory agent, it is used to manage acute exacerbations of chronic inflammatory diseases such as:
- Rheumatoid arthritis
- Ankylosing spondylitis
- Osteoarthritis
Mechanism of Action of Diclofenac 75mg/ml
Diclofenac exerts its therapeutic effects by inhibiting the cyclooxygenase (COX) enzymes, specifically COX-1 and COX-2. These enzymes are responsible for converting arachidonic acid into prostaglandins—compounds that mediate pain, inflammation, and fever. By blocking this pathway, Diclofenac effectively reduces the cardinal signs of inflammation and alleviates pain.
Dosage and Administration Guidelines
For administration by a Registered Medical Practitioner only.
- Standard Adult Dose: 1 ampoule (75mg) administered once daily via a deep intragluteal (intramuscular) injection into the upper quadrant.
- Severe Cases: The dose may be increased to two 75mg injections daily, administered at separate sites.
- Duration: Injectable Diclofenac is generally intended for short-term use (typically not exceeding two days). For continued therapy, treatment should be switched to an oral or rectal formulation.
Safety Profile: Contraindications and Adverse Effects
A thorough patient history is crucial before administering Diclofenac Injection.
Contraindications
Diclofenac Injection should NOT be used in patients with:
- Known hypersensitivity to Diclofenac, aspirin, or other NSAIDs.
- Active gastric or intestinal ulceration, bleeding, or perforation.
- Severe cardiac, hepatic, or renal failure.
- The last trimester of pregnancy.
Potential Adverse Effects
Common side effects may include reactions at the injection site (pain, induration), nausea, headache, and dizziness. Serious but less common adverse events can include gastrointestinal bleeding, hypertension, and fluid retention.
Drug-Drug Interactions
Caution is advised when co-administering with other medications, including:
- Lithium and Digoxin: Diclofenac may increase their plasma concentrations.
- Diuretics and Antihypertensives: It may reduce their efficacy.
- Other NSAIDs and Corticosteroids: Increased risk of gastrointestinal adverse effects.
Frequently Asked Questions:
How quickly does Diclofenac Injection 75mg/ml work?
When administered intramuscularly, Diclofenac injection typically begins to relieve pain within 15-30 minutes, with peak effects observed in about one hour.
Is Diclofenac Injection used for kidney stone pain?
Yes, due to its potent analgesic and anti-inflammatory properties, Diclofenac injection is frequently used for the management of acute pain associated with renal colic (kidney stones).
What is the standard dose for an adult?
The usual dose for adults is one ampoule (75mg) once daily, administered via deep intramuscular injection. Always follow a healthcare professional’s prescription.
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Disclaimer:
Disclaimer: All the information available on this site is for educational and informational purposes only. The information provided should not be used for the diagnosis or treatment of any health problem without expert advice. Always seek the guidance of a qualified medical practitioner for medical examination and treatment. Do not self-administer this injection.
References:
- Diclofenac (Intravenous Route) – [Mayo Clinic]
- Diclofenac sodium salt – [BioTechne]
- Diclofenac is more effective for postoperative analgesia… – [PMC4173621]
Reviewed by:
- Name: Dr. Yogesh Chaudhary
- Qualifications: B.Pharma
- Title: Senior Pharmacist, S.N. Medical College, Agra (UP)
- Registration: Registered Pharmacist, UP Pharmacy Council (Reg. No: XXXXXX)
- Dr. Chaudhary has over 15 years of experience in clinical pharmacy and medication management.
Partner with Laafon Galaxy Pharmaceuticals
As a leading manufacturer of NSAID injections in India, we are committed to quality and partnership.
