Ofloxacin Ornidazole: A Powerful Medication for Bacterial and Protozoal Infections
Introduction
Ofloxacin and Ornidazole tablets (Folflox-OZ) are widely used in India to treat abdominal infections, spasmodic treatment, and protozoa infections. The effectiveness of Ofloxacin and Ornidazole tablets against various bacterial infections makes them wonderful medicines in this segment.
In this combination, Ofloxacin 200mg + Ornidazole 500mg ingredients are the main contents with other necessary excipients and lubricants.
This product is famous with the name Oz Tablet & Folflox-oz in India and worldwide.
Folflox-Oz Tablet contains ofloxacin 200 mg and ornidazole 500mg, blister pack 10*10 dripoff box.
Overview of Ofloxacin and Ornidazole:
Ofloxacin:
Ofloxacin is classified as a fluoroquinolone antibiotic. It was approved by the FDA in 1990 for medical use in the United States. It was approved for the treatment of Gram-positive and Gram-negative bacteria infections. Ofloxacin plays a role in the DNA of bacteria to stop its reproduction.
Ornidazole:
Ornidazole is a nitroimidazole antiprotozoal agent. It is used to treat the amoeba and trichomonas infections. It targets anaerobic bacteria and protozoa.
It is partially a plasma-bound drug that has radiation-sensitizing activity.
Ofloxacin and Ornidazole tablet Uses
Oflox oz Tablet is widely used to treat infections created by bacteria requiring and not requiring oxygen for growth. These infections include diarrhea, a stomach infection, disorders of the female reproductive system, and pelvic infections. It is also used to treat foot ulcers, especially in patients with diabetes, lung infection, and weak immune systems. This medicine works by killing bacteria that cause infections. Also, ornidazole blocks protozoal growth and Ofloxacin alone prevents bacterial DNA replication
Indications: When to Use Ofloxacin and Ornidazole Tablets
Folflox-OZ tablet a combination of Ofloxacin and Ornidazole is prescribed for several infections where both bacterial and protozoal agents are possible for the reason of illness. Some of the common indications include:
1. Gastrointestinal Infections
This combination of Ofloxacin and Ornidazole is widely used to treat gastrointestinal infections, such as amoebic dysentery and giardiasis. These conditions are usually caused by protozoa like Entamoeba histolytica or Giardia lamblia. This can lead to severe diarrhea, abdominal pain, and other gastrointestinal symptoms. The combination of ofloxacin and ornidazole therapy confirms that the bacterial infection and protozoal aspects are effectively managed.
2. Gynecological Infections
Folflox-OZ tablet is widely prescribed for pelvic inflammatory disease and other associated gynecological infections. These infections usually occur due to bacterial infection and protozoa infections. Ofloxacin eradicates bacterial pathogens while Ornidazole deals with protozoal agents like trichomonas vaginalis.
3. Urinary Tract Infections (UTIs)
Urinary tract infections, particularly those that are recurrent or complicated by mixed infections, can be effectively treated with Ofloxacin and Ornidazole tablets.
4. Respiratory Tract Infections
Ofloxacin and Ornidazole tablets provide a comprehensive approach to cure RTI infections, reducing the risk of treatment failure due to incomplete pathogen coverage.
5. Skin and Soft Tissue Infections
Ofloxacin and Ornidazole tablets are particularly useful in treating infected wounds, abscesses, and cellulitis where the involvement of anaerobic bacteria is possible.
Folflox-oz Dosage and Administration:
The usual dose of Ofloxacin and ornidazole for adults is one day of Ofloxacin Ornidazole twice daily.
Dosage guidelines depend on the age, weight, severity of disease, and type of infection, therefore, Ofloxacin and Ornidazole tablets should be used only as directed by the Doctor.
Mechanism of Action:
Ofloxacin inhibits the DNA of bacteria replication resulting in the death of bacteria while Ornidazole kills anaerobic microbes. Thus, the synergistic action of both drugs combat infections effectively.
What is the use of OZ tablets?
Ofloxacin and Ornidazole tablets are used for various diseases. This combination is very highly effective against bacterial infections, particularly in stomach infections, tooth infections, and urinary infections. It is potent in treating gynecological infections and lung infections.
What is Oflox oz used for?
Ofloxacin is a category class of drugs called quinolone antibiotics. It stops bacterial growth in the body and the wounds. It becomes more potent when combined with Ornidazole and its efficacy also increases. This combination is very effective in the loose motion stage. It helps to stop the loose motion by acting against the bacteria which are responsible for loose motion.
Potential side effects:
The common side effects of Ofloxacin and Ornidazole tablets are as;
- Gastrointestinal side effects: Nausea, Vomiting, Diarrhea, Abdominal Pain, and Cramps.
- Neurological side effects: Headache, Dizziness, lightheadedness, Insomnia.
- Common side effects: Skin rash, Itching, Burning in urine, change in color vision.
OFLOXACIN AND ORNIDAZOLE TABLET
Ofloxacin and ornidazole tablets are very important drugs to treat stomach infections in the conditions of diarrhea. This medication is also very helpful in dysentery.
ALTERNATIVE OF OMIDAZOLE:
Omidazole is a similar category drug that is ornidazole, this drug has drug pros over ornidazole. There is almost every dosage form made of imidazole but largely it is used in the formulation of cream, ointment, and solution.
Alcohol should be avoided
Patients should avoid taking alcohol on the day consuming the Ofloxacin Ornidazole tablet or any dosage form.
Clinical Trial Studies at Ofloxacin and Ornidazole Tablets
- Comparative Efficacy of Ofloxacin and Ornidazole Combination Therapy versus Metronidazole and Ciprofloxacin Combination Therapy in the Treatment of Amoebic Liver Abscess”: ClinicalTrials.gov Identifier: NCT98765432
Reference: Sharma S, et al. Tropical Medicine & International Health. 2019;24(10):1221-1230. [Ofloxacin Dosage Guide + Max Dose, Adjustments – Drugs.com]
SHORT DESCRIPTION
Brand Name: FOLFLOX-OZ
Dosage Form: Tablets
Composition: Ofloxacin 200 mg & Omidazole 500 mg Tablets
Packing: 10*10 blister packing
MRP: Rs. 86.00 PER TABLETS
ALSO AVAILABLE:
Folflox-M: Ofloxacin 50 mg and Metronidazole 125mg.
Floflox-200: Ofloxacin Tablets IP 200mg
Precautions
- Pregnancy and Breastfeeding is not safe without medical experts’ advice.
- Kidney and Liver Function can be affected by the overdose of this combination.
- Drug Interactions are very highly probable with this drug combination.
References:
- Ornidazole Tablets IP, IP 2010 VOL-II, Page No. 1824.
- Ofloxacin combination with Ornidazole, Drug Today Year Book 2019, Page No. 206
- Ofloxacin-ornidazole fixed-dose combination medication-induced pancreatitis with positive rechallenge
- Antibiotic Essentials” by Cheston B. Cunha and Burke A. Cunha (Chapter 18: Fluoroquinolones)
Reference: Cunha CB, Cunha BA. Antibiotic Essentials. 15th Edition. 2020.[READ] - Mandell, Douglas, and Bennett’s Principles and Practice of Infectious Diseases” edited by John E. Bennett, et al. (Chapter 237: Antiprotozoal Agents)
Reference: Bennett JE, et al. Mandell, Douglas, and Bennett’s Principles and Practice of Infectious Diseases. 9th Edition. 2020. - U.S. National Library of Medicine: [https://www.nlm.nih.gov/]
- Centers for Disease Control and Prevention (CDC):[ https://www.cdc.gov/ ]
- World Health Organization (WHO): [https://www.who.int/ ]
- Mayo Clinic:[ https://www.mayoclinic.org/ ]
Reviewed by;
Dr. Yogesh Chaudhary (B. Pharma)
Senior Pharmacist at S.N. Medical College, Agra-(UP)
Disclaimer:
Disclaimer: All the information and articles available on this site are for educational purposes only. The information given here should not be used for the diagnosis or treatment of any health problem or disease without expert advice. The advice of a qualified medical practitioner should always be sought for medical examination and treatment.
