Aceclofenac, Paracetamol and Serratiopeptidase tablets (Lace-SP) are a blend of three molecules that are used to treat pain, fever, and inflammation.Â
Aceclofenac is a nonsteroidal anti-inflammatory drug (NSAID) class drug. It works by blocking the production of certain hormones that is responsible for causing pain and inflammation, namely prostaglandins.
Paracetamol is a well-known analgesic and antipyretic drug that helps to get relief from pain and fever. Serratiopeptidase is an enzyme that is used to treat inflammation and swelling. The synergistic effects of three molecules make this tablet a strong pain reliever medicine.
Table of Contents
Medical Conditions Addressed Lace-SP tablet:
Lace-SP is an aceclofenac Paracetamol and serratiopeptidase tablet which is used for pain relief. It also relieves pain in conditions like headaches, mild migraines, musculoskeletal pain, or painful menses, Lace-SP orange colored is a film-coated tablet. Served in elegance alu alu packing.
The most common medical conditions that are addressed by this combination:
A. Arthritis and Joint Pain: Aceclofenac, Paracetamol, and Serratiopeptidase tablets are found to be very effective in all types of arthritis like Osteoarthritis, Rheumatoid arthritis, and joint pain. Aceclofenac and paracetamol provide a strong pain-relieving therapy in such conditions. Otherside, Serratiopeptidase provides relief from inflammation and swelling due to various reasons.
B. Inflammatory Disorders: This combination is very suitable in inflammatory disorders, the trio-effects of this tablet provide a multidimensional relief on the situation.
C. Postoperative Pain Management: Lace-SP is very effective in postoperative pain management conditions. The role of this tablet is very decisive in bone-related surgeries. It is not only a pain reliever but is safer than diclofenac sodium as painkillers.
Aceclofenac Paracetamol and Serratiopeptidase Tablets uses:
Lace-SP Aceclofenac Paracetamol and Serratiopeptidase Tablets are used for pain relief. It also relieves pain in conditions like headache, mild migraine, musculoskeletal pain, or painful menses, It is very helpful in the relief of pain and inflammation in osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis in adults
LACE-SP INGREDIENTS DESCRIPTION
Serratiopeptidase–
Serratiopeptidase (Serratia E-15 protease, also known as serralysin, serrapeptase, serratiapeptase, Serratia peptidase, serratiopeptidase, or serratiopeptidase), is a proteolytic enzyme (protease) produced by non-pathogenic enterobacteria Serratia sp. E-15, now known as Serratia marcescens ATCC 21074. This microorganism was originally isolated in the late 1960s from silkworm bombyx Mori L. (intestine), Serratiopeptidase is present in the silkworm intestine and allows the emerging moth to dissolve its cocoon. Serratiopeptidase is produced by purification from the culture of Serratia E-15 bacteria. It is a member of the Peptidase M10B (Matrixin) family.
Aceclofenac-
Aceclofenac is a nonsteroidal anti-inflammatory drug (NSAID) analog of diclofenac. It is used for the relief of pain and inflammation in rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis.
Aceclofenac was patented in 1983 and approved for medical use in 1992.
CHEMISTRY OF ACECLOFENAC –
Aceclofenac (C16H13Cl2NO4), chemically [(2-{2, 6-chlorophenyl) amino} phenylacetooxyacetic acid], is a crystalline powder with a molecular weight of 354.19. It is practically insoluble in water with good permeability. It is metabolized in human hepatocytes and human microsomes to form [2-(2′,6′-dichloro-4′-hydroxy- phenylamino) phenyl] acetoxyacetic acid as the major metabolite.
Paracetamol:
Paracetamol, also known as acetaminophen, is a medication used to treat pain and fever. It is typically used for mild to moderate pain relief. Evidence is mixed for its use to relieve fever in children. It is often sold in combination with other medications, such as in many cold medications. Paracetamol is also used for severe pain, such as cancer pain and pain after surgery, in combination with opioid pain medication. It is typically used either by mouth or rectally but is also available by injection into a vein. Effects last between two and four hours
Paracetamol is generally safe at recommended doses. The recommended maximum daily dose for an adult is three to four grams. Higher doses may lead to toxicity, including liver failure. Serious skin rashes may rarely occur. It appears to be safe during pregnancy and when breastfeeding. In those with liver disease, it may still be used, but in lower doses. It is classified as a mild analgesic. It does not have significant anti-inflammatory activity. How it works is not entirely clear.
Paracetamol was first made in 1877. It is the most commonly used medication for pain and fever in both the United States and Europe. It is on the World Health Organization’s List of Essential Medicines. Paracetamol is available as a generic medication, with brand names including Tylenol and Panadol among others. The wholesale price in the developing world is less than US$0.01 per dose. In the United States, it costs about US$0.04 per dose. In 2017, it was the 25th-most commonly prescribed medication in the United States, with more than 24 million prescriptions.
Lace-SP Indication
Aceclofenac Paracetamol and serratiopeptidase tablets have the following Indications:
- Fever and flu
- Bone and joint pain
- Rheumatoid Arthritis
- Osteoarthritis
- Headache
- Mild migraine pain
- Toothache
- Ankylosing spondylitis
- Menstrual pain
- Cold and sore throat
- Inflammation (swelling)
Lace-SP Possible Side-effects:
These are some side-effects that may be associated with Aceclofenac Paracetamol and serratiopeptidase tablet
- Abdominal pain
- Dizziness
- Emesis (vomiting)
- Dyspepsia (indigestion)
- Allergic reaction (Skin redness and rashes)
- Loss of appetite
- Hepatic (liver) damage
- Kidney Failure
PRECAUTION IN ACECLOFENAC PARACETAMOL AND SERRATIOPTIDASE TABLET:
LACE-SP i.e. Aceclofenac Paracetamol and Serratiopeptidase Tablets is covered in Schedule H Drugs Since Schedule H Medicines are advised to be taken only after a Doctor’s prescription you should not take this medicine by your own decision. This combination contains three medicaments which all have many drug Interactions and possible reaction chances, and should not be used without a prescription.
- Women in pregnancy and lactation should not take.
- Since this combination has slightly sedative properties do not take it prior to driving
- Do not co-administer alcohol
- In Gastric Ulcers should not be used.
- Should not be used for asthma
SIMILAR PRODUCTS:
Aceclofenac Paracetamol and Serratiopeptidase tablets brand names:
| Sr. No. | Product Name | Company Name |
| 1 | ZERODOL-SP | Ipca Laboratories Ltd |
| 2 | SIGNOFLAM | Lupin Ltd |
| 3 | IBUGESIC ASP | Cipla Ltd |
| 4 | ACE-PROXYVON SP | Wockhardt Ltd |
| 5 | FLOZEN-AA | Mankind Pharma Ltd |
Controversies associated with this combination:
The Health Department of the Indian Government issued a notice to all States and UTI’s Drug Controllers to withdraw the permission to manufacture 294 FDCs that were opposed to use by several consumer associations. The first time, the issue was raised in 2007, In December 2018, CDSCO issued notices to all state drug controllers to cancel permissions of above said 294 FDCs. However, CDSCO allowed 49 FDCs from 294 to manufacture them after submitting sufficient clinical trial data in support of these items. Aceclofenac, Paracetamol, and Serratiopeptidase tablets are 3 molecules of FDC that were also needed to submit clinical trial data that support the effectiveness of this combination over two molecules (Serratiopeptidase and Paracetamol) FDC.
Short Description:
Brand Name: LACE-SP TABLETS
Composition: Aceclofenac 100mg. + Paracetamol 325mg..+Serratiopeptidase 15mg.
Packing: 10*10 Alu Alu
MRP: Rs. 110.00
Also Available;
LACE-P TABLET (Aceclofenac–Paracetamol Tablets)
Down-A Susp (Aceclofenac–Paracetamol suspension)
LAADIC-SP TABLET (Diclofenac+Paracetamol+Serratiopeptidase)
References:
- What is Aceclofenac?-[MedicoverHospitals(.in)]
- Aceclofenac-Wikidoc(org)
Reviewed by;
Dr. Yogesh Chaudhary (B. Pharma)
Senior Pharmacist at S.N. Medical College, Agra-(UP)
Disclaimer:
Disclaimer: All the information and articles available on this site are for educational purposes only. The information given here should not be used for the diagnosis or treatment of any health problem or disease without expert advice. The advice of a qualified medical practitioner should always be sought for medical examination and treatment.
