Cefpodoxime Uses, Dosage, and Side Effects:
Cefpodoxime oral suspension IP i.e. POSTPOD DRY SYRUP is a cephalosporin antibiotic. It is used to treat various types of bacterial infections such as ear infections, sinus infections, throat infections, and urinary tract infections. It is recommended for children who can not swallow Cefpodoxime tablets.
Cefpodoxime oral suspension is an important dosage forms children below 6 years of age because they are not comfortable taking tablets of this drug. It is also found faster dissolution rate in the stomach in comparison to tablets.
Cefpodoxime is a third-generation cephalosporin family antibiotic. Its working mechanism is to stop the growth of bacteria. It is effective against a wide range of bacteria including Gram+ and Grarm negative bacteria.
Understanding Cefpodoxime as a medicine
Cefpodoxime Proxetil is a third-generation cephalosporin antibiotic that is highly effective against bacterial infections where Cefixime and Amoxiclave failed to treat infections.
What is Cefpodoxime?
CEFPODOXIME (sef pode OX eem) is a potent antibiotic that was developed in 1980 by Hoechst Marion Roussel. First time in 1989 Cefpodoxime was approved by the FDA for medicinal use in the United States.
The chemical name of Cefpodoxime Proxetil is (RS) 1(isopropoxycarbonyloxy) ethyl (+)-(6R,7R)-7-[2-(2-amino-4- thiazolyl)-2-{(Z)methoxyimino}acetamido]-3 methoxymethyl-8-oxo-5-thia-1-azabicyclo [4.2.0]oct-2-ene- 2-carboxylate.
Cefpodoxime proxetil molecular weight is 557.6
Mechanism of Action of Cefpodoxime oral suspension:
Cefpodoxime is a cephalosporin category medicine that works by inhibiting the synthesis of specific bacterial cell walls. These bacterial cells are an essential step for the integration of the structure of bacteria. Cefpodoxime stops the whole sequence of processes by inhibiting bacterial cell wall synthesis.
Cefpodoxime is active against a wide range of Gram-positive and Gram-negative bacteria, including; Streptococcus pneumonia, Staphylococcus aureus, Escherichia coli, Proteus mirabilis
Haemophilus influenza, and Neisseria gonorrhoeae.
Benefits of Oral Suspension Form
There are several benefits of oral suspension over oral tablet form, some of which are listed below:
- The advantages of oral suspension over other dosage forms are significant due to its liquid form.
- Ease of administration for children and elderly patients who can not swallow tablets.
- Improved bioavailability and absorption in oral suspension in comparison to tablets.
- Enhanced patient compliance due to its sweet taste and easy to take.
Indications of Cefpodoxime Oral Suspension IP:
Who is susceptible to mild to moderate infections including acute otitis media, acute bacterial exacerbations of chronic bronchitis, acute maxillary sinusitis, pharyngitis/tonsillitis, acute community-acquired pneumonia, urinary tract, skin, and skin structures; cervical, anorectal (females only), and urethral gonorrhea. It is indicated in community-acquired pneumonia, uncomplicated skin and skin structure infections, and uncomplicated urinary tract infections.
Proper Usage and Dosage:
Use reconstituted suspension with water in the box.
- <2 months: not recommended.
- 2 months–12 yrs: Max 200mg in a day, divided into two doses for 5 days.
- Acute otitis media: 5mg/kg (max 200mg) every 12 hours for 5 days.
- For Pharyngitis/tonsillitis: 5mg/kg (max 100mg) every 12 hours for 5–10 days.
- For Sinusitis: 5mg/kg (max 200mg) every 12 hrs for 10 days.
Safety and Precautions:
Common Side EffeaZcts:
The most common side effects of Cefpodoxime dry syrup include rash, nausea, and diarrhea. Taking this medicine along with some food may help to prevent indigestion and upset stomach. Consult the doctor if you find these side effects bother or worry you.
Before using it, you should tell your doctor if you are allergic to any antibiotics or have any kidney or liver problems. This medicine is generally regarded as safe to use in pregnancy and breastfeeding if prescribed by your doctor. It may blur your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
Allergic reactions and when to seek medical assistance:
Cefpodoxime is a safe medicine on most occasions. but if you feel any allergies like signs on your skin, problems in breathing, rashes, etc, you immediately report to a doctor and consult with him about the medicine you have taken and your conditions.
Precautions for patients with specific medical conditions:
If you have an allergy to any cephalosporin medicines like Cefixime, Ceftriaxone, Cefuroxime, etc, then you should not take this medicine. If you have any kidney-related issues then you first consult your doctor and then take the revised dose by the doctor.
Drug interactions to be aware of:
Cefpodoxime can interact with other drugs if they are used simultaneously with it. Some drugs that can interact with cefpodoxime are listed below:
- Antacids
- Diuretics
- Histamine H2-receptor antagonists, Cimetidine (Tagamet), Famotidine (Pepcid), Nizatidine (Axid)
- Probenecid
- Nephrotoxic drugs
Storage and Shelf Life:
Proper storage conditions for Cefpodoxime oral suspension:
Store at a dry, dark, and cool place. Store at a temperature below 25oC. protect from light and moisture. Keep out of reach of children.
Shelf life and expiration date:
The shelf life of Cefpodoxime oral suspension is 24 months from the date of manufacturing. Use the reconstituted suspension within 7 days of reconstitution.
Clinical Trial and Studies on Cefpodoxime:
A clinical trial (NCT00194532) was performed with the sponsorship of the University of Washington. The clinical trial started in 2005 and was completed in February 2009. It was performed on 300 patients. In this clinical trial, Ciprofloxacin was found more effective than Cefpodoxime in treating acute cystitis in women.
A clinical trial to Evaluate the Safety, Tolerability, and Pharmacokinetics of ETX0282 when administered orally to healthy Participants, was started on 16.03.2018 and completed on 11.09.2019, Total number of enrollments was 99. It was found well tolerated by healthy patients.
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Postpod dry syrup
Composition of Postpod (CefpodoximeDry Syrup):
Each 5ml after Reconstitution contains
Cefpodoxime Proxetil IP Equivalent to Cefpodoxime 50mg
About Postpod dry syrup:
Postpod-50 mg Dry Syrup (Cefpodoxime dry syrup) is a third-generation cephalosporin antibiotic medicine used to treat bacterial infections in a kid’s body. It is very effective in infections of the lungs (eg. pneumonia), and the urinary tract, It is active against most Gram-positive and Gram-negative organisms. It also finds use as oral continuation therapy when intravenous cephalosporins (such as ceftriaxone) are no longer necessary for continued treatment.
Postpod-50 mg Dry Syrup should be taken with food. It should be taken regularly at evenly spaced intervals as per the schedule prescribed by the doctor. The dose will depend on what diseases the patient is being treated for, Do not stop taking it until the whole bottle has finished, even when the patient feels better. It will not work for viral infections such as the flu or the common cold. Using any antibiotic when the patient does not need it can make it less effective for future infections.
Short Description
- Brand Name: POSTPOD
- Dosage Form: Dry syrup
- Composition: Cefpodoxime Proxetil 50mg/5ml
- Packing: 30 ml
- MRP: Rs. 92.00
Also Available:
POSTPOD-200 Tablet: (Cefpodoxime 200 mg)
CEFFON-50 DRY SYRUP: (Cefixime 50mg/5ml)
LAAMOX-CV DRY SYRUP: (Amoxycillin 200mg+Clavulanic Acid 28.5 mg/5ml)
References
- Cefpodoxime Oral Suspension [ClevelandClinic]
- Vantin® Tablets and Oral Suspension-Access Data [FDA(.gov)]
- Cefpodoxime- Mechanism of Action [Go-Drugbank-online]
Disclaimer:
Disclaimer: All the information and articles available on this site are for educational purposes only. The information given here should not be used for the diagnosis or treatment of any health problem or disease without expert advice. The advice of a qualified medical practitioner should always be sought for medical examination and treatment.
Reviewed by;
Dr. Yogesh Chaudhary (B. Pharma)
Senior Pharmacist at S.N. Medical College, Agra-(UP)
