Lobular Plus | Itraconazole Ofloxacin Ornidazole Clobetasol propionate Cream

What is the uses of itraconazole Ofloxacin Ornidazole clobetasol propionate cream?

Itraconazole Ofloxacin Ornidazole & Clobetasol propionate cream i.e. Lobular-Plus is a combination ointment that is used to treat several skin infections, including bacterial, fungal, and parasitic infections. The cream contains four active ingredients:

• Ofloxacin is an antibiotic that kills bacteria by preventing them from reproducing.
• Ornidazole is an antibiotic that kills a variety of microorganisms, including bacteria, parasites, and fungi.
• Itraconazole is an antifungal medication that kills fungi by destroying their cell membranes.
• Clobetasol propionate is a corticosteroid that reduces inflammation and itching.

Multi-molecule combination creams are becoming increasingly important in dermatology because they can provide more effective treatment for skin infections than single-ingredient creams. Therefore, different active ingredients in a cream work together to heal the infection from different perspectives. For example, Ofloxacin and Ornidazole can kill bacteria, fungi, and parasites, which makes them a more effective treatment for a wider range of skin infections, while, Itraconazole and Clobetasol play an anchor role to reduce inflammation and protecting the skin. 

Understanding the Ingredients:

This cream contains Itraconazole, Ofloxacin, Ornidazole, and Clobetasol Propionate. The role of different molecules is discussed separately:

Exploring Ofloxacin: A Broad-Spectrum Antibiotic:

Ofloxacin is a broad-spectrum antibiotic. It is used to treat several types of bacterial infections. Ofloxacin works by binding DNA gyrase protein. It is an enzyme that helps to replicate bacterial DNA. Ofloxacin binds to DNA gyrase which prevents enzymes from replicating their DNA and kills them. 
It is effective against Gram-negative bacteria like Escherichia coli, Salmonella, and Shigella. It is also very effective in Gram-positive bacteria such as Staphylococcus aureus and Streptococcus pneumonia Some anaerobes,  
It is effective against several types of skin infections when used in external preparation with Itraconazole, Ornidazole, and Clobetasol Propionate. It helps relieve symptoms such as pain, redness, itching, or soreness caused due to eye infections.

Ornidazole: A Potent Antiprotozoal Agent:

Ornidazole is an antiprotozoal agent that is used to treat a variety of infections generated by protozoans. Ornidazole disturbs the structure of the DNA of protozoans. Ornidazole is effective against Trichomonas vaginals, Entamoeba histolytica, Giardia lamblia, and Helicobacter pylori. The role of Ornidazole in an external preparation is different from its oral use. It plays a vital role in a cream with other ingredients like Ofloxacin, Itraconazole, and Clobetasol Propionate. 

Itraconazole: An Effective Antifungal Medication:

Itraconazole is an antifungal medicine that is used to treat several types of fungal infections, skin infections, nail infections, and mucous membranes. It is also available in oral and topical forms. Itraconazole inhibits the growth of fungi. It blocks the production of ergosterol, a component of the fungal cell membrane. It helps to make cell membranes weak and leaky which becomes the ultimate reason for the eradication of fungus.

Itraconazole ointment is typically used to treat:

• Tinea pedis (athlete’s foot)
• Tinea cruris (jock itch)
• Tinea corporis (ringworm)
• Candidiasis (yeast infection)
• Pityriasis versicolor (a fungal infection that causes discolored patches on the skin)

Clobetasol Propionate: A Powerful Topical Corticosteroid:

Clobetasol is a strong corticosteroid that is useful in inflammation, swelling, and skin redness. It becomes a supportive agent with Ofloxacin, Ornidazole, and Itraconazole in a cream. 

Itraconazole Ofloxacin Ornidazole & Clobetasol propionate Cream Uses:

Lobular Plus (Itraconazole + Ofloxacin + Ornidazole + Clobetasol cream) cream is used to treat various types of skin infections. This is the latest and most prominent formula against modern-day infections on the skin and head. This combination is very effective in harpies’ skin disease and leopardsy.

This combination is also proven well effective in wart and sobi skin disease. In ringworm, sarpi, and Dadar disease it has more effective than other miconazole-based derma creams. Itch Guard is another alternative for skin itching. 

SKIN DISORDER TREATMENT

Many skin disorders are treated with Itraconazole + Ofloxacin + Ornidazole + Clobetasol cream because this formula provides a balanced activity against every fungal and bacterial infection.

Hives skin disease when minor red mildy painful itches develop on the skin, this medication acts strongly against that disease.

Actinic keratosis is a serious skin disease that remains about 2 cm in size on skin pink color wound type and is also treated with this combination successfully.

In Rosacea skin disease Lobular Plus cream is very effective, this is a chronic skin disease that requires high alert for a cure. 

Proper Usage and Application:

Dosage Instructions:

The dosage of the Ofloxacin, Ornidazole, Itraconazole, and Clobetasol cream depends on the type of skin infection, age, and part of the body. Follow the instructions of the doctor for the usage of the cream. However, it is available on OTC product, but further, it is important to ask the doctor before using the cream.

Precautions and Contraindications:

It is very important to avoid any side effects of the medicine by following the guidance of a doctor. Do not use this cream without the recommendations of a doctor. Consult the doctor if your skin is sensitive to any one of the ingredients present in the cream. 

These contraindications may include: 

• Pregnancy and breast-feeding: Itraconazole, ofloxacin, and ornidazole can all cross the placenta and enter the bloodstream of a developing fetus. They can also be passed through breast milk to a nursing infant. Therefore, these medications should not be used during pregnancy or breastfeeding unless the benefits outweigh the risks.
• Kidney disease: Ofloxacin and ornidazole can both be nephrotoxic, meaning they can damage the kidneys. Therefore, these medications should not be used in people with kidney disease. Do not swallow the cream, and keep it out of reach of children.
• Allergic reactions: Itraconazole, ofloxacin, and ornidazole can all cause allergic reactions. If you have had an allergic reaction to any of these medications in the past, you should not use them again.
• Other medications: Itraconazole, ofloxacin, and ornidazole can interact with other medications. Therefore, it is important to tell your doctor about all of the medications you are taking before starting treatment with any of these medications.

Application Techniques for Optimal Results:

The method of application of the cream is similar to other creams are applied. Take a pie size amount of cream on your fingertip and apply the cream on the affected area gently. Use only after proper cleaning of the place, clean the place every time before applying the cream. For specific instructions, ask your dermatologist.  

Lobular Plus- the perfect solution for skin infections:

Lobular-Plus is a combination of  Ofloxacin Ornidazole Itraconazole and Clobetasol. This is the most prominent antifungal formula working in India. It has four ingredients that are very trusted against skin infections.

Ofloxacin is an antibiotic that kills bacteria by preventing them from reproducing and repairing themselves. Ornidazole is also an antibiotic that kills other infectious microorganisms in addition to bacteria by damaging the DNA. Itraconazole is an antifungal medication. It kills and stops the growth of the fungi by destroying their cell membrane, thereby treating your skin infection. Clobetasol is a steroid medicine. It blocks the production of certain chemical messengers (prostaglandins) that make the skin red, swollen, and itchy.

Also Read: Pain Management: Understanding Different Approaches and the 4A’s in Effective Pain Management

SHORT DESCRIPTION

Brand: LOBULAR+

Composition: Ofloxacin 0.75%,Ornidazole 2.00%,Itraconazole1.00%, . Clobetasol 0.05%w/w

Dosage Form: CREAM

PRODUCT LIFE: 2 YEARS

PACK SIZE: 15 GM LAMI TUBE

MRP: 79.00 PER TUBE

Also Available;

LOBULAR-GM: (Clobetasol Propionate 0.5%, Neomycin Sulphate 0.5 %, Miconazole Nitrate  2% Cream.

Faster gel: Diclofenac, Linseed Oil, Salicylic acid, and Menthol gel

Tinto-MH Cream: (Mometasone, Tretinoin, and Hydroquinone Cream)

COZICOF-LS : Ambroxol Hcl 15 mg+Levasalbutamol 1mg.+Guaiphenesin 50mg/5 ml

Fonvital Plus: Ginseng with Multivitamins, Minerals & Antioxidants capsules

Mecome-Alpha: Methylcobalamin alpha-lipoic acid pyridoxine Hydrochloride,  folic acid, and Thiamine Mononitrate

DOWN-A SUSPENSION: Aceclofenac and Paracetamol suspension

 GCYP PLUS: Cyproheptadine tricholine and citrate syrup 

Itco-200: Itraconazole capsules 200 mg

Laadic-MR Tablet: Diclofenac Potassium, Chlorzoxazone and Paracetamol Tablet.

Frequently Asked Questions (FAQs):

References: 

• CLOBEX® (clobetasol propionate) Lotion, 0.05%, for topical use Initial U.S. Approval: 1985 [Food and Drug Administration(.gov)]
• Ofloxacin: A Reappraisal of its Antimicrobial Activity, Pharmacology, and Therapeutic Use, by:- Peter A. Todd & Diana Faulds [Springer Link]
• Assessment of antifungal efficacy of itraconazole loaded aspasomal cream: a comparative clinical study [National Library of Medicines(PubMed central)]

Disclaimer:

Disclaimer: All the information and articles available on this site are for educational purposes only. The information given here should not be used for the diagnosis or treatment of any health problem or disease without expert advice. The advice of a qualified medical practitioner should always be sought for medical examination and treatment.

Reviewed by:

Dr. Yogesh Chaudhary (B. Pharma)

Senior Pharmacist at S.N. Medical College, Agra-(UP)