Understanding Nimesulide and Paracetamol Tablets: Uses, Dosage, and Side Effects

Nimesulide and paracetamol Tablets are top analgesics and antipyretics which has several medical uses. Laanim Plus is a high-quality product manufactured in GMP conditions and passes all tests for tablets. This is offered in a blister pack, yellow-colored tablets, clear PVC, and 10*10s packing in a carton.

Nimesulide and Paracetamol are pain relievers in nature, however, their mechanism of action is totally different from each other. Nimesulide is a nonsteroidal anti-inflammatory drug (NSAID), that reduces the pain in the body. Paracetamol is a top-class analgesic that blocks the pain signals before reaching the brain.

Nimesulide is available over-the-counter in India, however, it is a prescription drug covered in the Schedule-H drugs category. Paracetamol is available over the counter in India and most countries.

Nimesulide and Paracetamol Tablet | Laanim Plus — Nimesulide and Paracetamol Tablets | Laanim Plus

NIMESULIDE & PARACETAMOL TABLETS USES

Nimesulide is a nonsteroidal anti-inflammatory drug (NSAID) with pain medication and fever-reducing properties. Its FDA-approved indications are the treatment of acute pain, the symptomatic treatment of osteoarthritis, and primary dysmenorrhoea in adolescents and adults above 12 years old.

Paracetamol

Paracetamol (Acetaminophen) is a pain reliever and a fever reducer. The exact mechanism of action of paracetamol is not known. Paracetamol is used to treat many conditions such as headaches, muscle aches, arthritis, backache, toothaches, colds, and fevers. This combination is much safer than the Ibuprofen AND Paracetamol combination used for the same symptoms, Used in Migraine pain in early and medium pain. Widely used for severe fever conditions when alone Paracetamol does not work.

Nimesulide

Nimesulide is a nonsteroidal anti-inflammatory drug. It is a C-nitro compound a sulfonamide and one aromatic ether. It is related to the nitrobenzene group.

It is recommended only for 15 days in the treatment. The maximum dose for a day is 200 mg.

It is unpopular for liver toxicity in some cases. Despite its risk of hepatotoxicity the European Medicines Agency(EMA) in 2012 evaluation found is favorable in benefit/risk profile with other NSAIDs.

SIDE EFFECTS OF NIMESULIDE AND PARACETAMOL

Nimesulide and Paracetamol tablets are beneficial in many diseases but they have some side effects if they are taken without a prescription and in overdose. The use of Nimesulide is prohibited in children below 12 years of age. Nimesulide may lead to some serious implications for children. Long-term use of Nimesulide may lead to a low rate of transient serum enzyme elevations in patients. Paracetamol is injurious to the liver if taken more than the prescribed dose. Paracetamol is used but is not advised if liver problems persist. The recommended dose in 24 hours should not be exceeded because it can lead to liver failure or even death in rare cases.

Some common side effects of Nimesulide and Paracetamol tablets;

Nausea
Vomiting
Diarrhea
Increased liver enzymes
Face swelling
Liver disease

Short description

Brand Name: LAANIM PLUS

Dosage Form: Tablets

Composition: Nimesulide 100 mg & Paracetamol 325 mg Tablets

Packing: 10*10 Blister

MRP: Rs. 55.00

SELF-LIFE: 2 YEARS

Warning for children below 12 years of age:

Warning: Not for use in children below 12 years of age.

Warning: Use of Nimesulide should ordinarily be restricted to 10 days, if longer clinical use is warranted, liver function test should be assessed periodically.

Warning: Taking more than a daily dose of Paracetamol may cause serious liver damage or allergic reactions(e.g. swelling of the face, mouth & throat, difficulty in breathing, itching, or rash.)

Pregnancy and lactation:

If you are a pregnant woman or you are feeding a baby then you should use this combination with the advice of a doctor. Nimesulide is known for contradicated in the pregnancy.

Substitutes for Laanim Plus Tablets:

Product Name	Manufacturer’s Name	MRP (₹)
Nicip Plus Tablet	Cipla Limited	65.10
Nodard Plus Tablet	Cipla Limited	57.75
Nimucet Gold 100mg/325mg Tablet	Intas Pharmaceuticals	58.50
Nimprex-P Tablet	Seagull Pharmaceuticals	50.82
Nobel-Plus Tablet	Mankind Pharma	74.50
Dolide Plus Tablet	Sun pharmaceuticals Limited	81
Nimupain Plus Tablet	Cipla Limited	62
Nimulid HF Tablet	Panacea Biotech Limited	75.7
NAP PLUS TABLET	Cubit Healthcare	24.68
Nimbond P Tablet	Aurz Pharmaceuticals	49.3

Who should not use Nimesulide+Paracetamol Tablets;

Nimesulide is a nonsteroidal anti-inflammatory (NSAID) that is used for pain relief usually for headache and back pain. It is not an OTC pain reliever, it is a prescription medicine that should not be used without the advice of a doctor. It is not a first-line treatment for pain. However, Paracetamol is more safer than Nimesulide but in combination with each other it becomes more strong and dangerous for compromised organs.

Children under 12 years old: Nimesulide is not recommended for use in children under 12 years old because of the risk of serious liver damage.
Pregnant women or women who are breastfeeding: Nimesulide+ Paracetamol can cause harm to a developing baby and should not be used by pregnant women or women who are breastfeeding.
People with a history of liver or kidney disease: Nimesulide+ Paracetamol can worsen liver or kidney damage and should not be used by people with a history of these conditions.
People with a history of stomach ulcers or bleeding: Nimesulide+ Paracetamol can increase the risk of stomach ulcers or bleeding and should not be used by people with a history of these conditions.
People with severe heart failure: Nimesulide+ Paracetamol can worsen heart failure and should not be used by people with severe heart failure.
People with allergies to NSAIDs: Nimesulide+ Paracetamol is an NSAID and can cause allergic reactions in people who are allergic to other NSAIDs.

Also Available;

DOWN-650 (Paracetamol 650mg)

FEFON-XT-SYRUP: Ferrous Ascorbate eq. to elemental Iron 30mg AND Folic Acid 550 mcg

FASTER GEL: (Linseed Oil 3%, Diclofenac Sodium 1%, Methyl Salicylate 10 % and Menthol 5% Gel.)

Foncef- SB-1.5g (Ceftriaxone 1gm+Sulbactam500mg)

Foncef-1gm (Ceftriaxone 1gm)

LOBULAR-GM: (Clobetasol Propionate 0.5%, Neomycin Sulphate 0.5 %, Miconazole Nitrate 2% Cream.

References:

Nimesulide-[Wikipedia(https://en.wikipedia.org/wiki/Nimesulide)]
Nimesulide+Paracetamol-[Tata1mg(https://www.1mg.com/generics/nimesulide-paracetamol-402515)]
LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet][National Library of Medicine]
Use of nimesulide in Indian children must be stopped; Journal List, BMJ, v.326(7391); 2003 Mar 29, PMC1125612-[PMC PubMed Central]
Use of Nimesulide During Early Pregnancy and the Risk of Congenital Malformations: A Population-Based Study from Italy, Anna Cantarutti, Matteo Franchi, Federico Rea, Luca Merlino, Giovanni Corrao, Affiliations expand; PMID: 29923044, DOI: 10.1007/s12325-018-0735-8;[PMC PubMed Central]

Disclaimer:

Disclaimer: All the information and articles available on this site are for educational purposes only. The information given here should not be used for the diagnosis or treatment of any health problem or disease without expert advice. The advice of a qualified medical practitioner should always be sought for medical examination and treatment.

Reviewed by;

Dr. Yogesh Chaudhary (B. Pharma)

Senior Pharmacist at S.N. Medical College, Agra-(UP)